【摘要】

摘要：目的：探讨丙戊酸钠联合利培酮治疗癫痫所致精神障碍的有效性与安全性。
方法：将医院2014年1月-2016年12月期间收治的168例癫痫性精神障碍患者作为研究对象，采用简单随机的
方法分为对照组与观察组，对照组使用丙戊酸钠治疗，观察组在从基础上联合利培酮治疗。比较两组患者PANSS评分、认知功能、不良反应等，并对临床疗效进行评价。
结果：治疗后，两组患者阳性量表、阴性量表、精神病理和总分均有明显的下降，其中观察组明显低于对照组（P＜0.05）；观察组治疗总有效率90.48%明显高于对照组77.38%（P＜0.05）；治疗前后，两组患者MMSE评分组间比较均无差异（P>0.05），且治疗后与治疗前相较无显著差异（P>0.05）；治疗后，观察组TESS评分为（8.34±2.71），对照组TESS评分为（8.12±2.64）（P>0.05）。
结论：丙戊酸钠联合利培酮治疗癫痫性精神障碍疗效显著，对患者认知功能影响小，副作用轻，值得推广。

【Abstract】

Abstract:Objective: To investigate the efficacy and safety of sodium valproate combined with risperidone in the treatment of epileptic mental disorders.
Methods: 168 patients with epileptic mental disorder in our hospital from January 2014 -December 2016 were selected as the research subjects. They were randomly divided into the control group and the observation group.The control group was treated with sodium valproate, and the observation group was treated with risperidone on the basis of the treatment.The PANSS score, cognitive function and adverse reaction were compared in the two groups, and the clinical efficacy was evaluated.
Results: After treatment, the positive scale, negative scale, mental pathology and total score of the two groups were significantly decreased, and the observation group was significantly lower than that of the control group, with significant difference (P<0.05).The total effective rate of treatment in the observation group was 90.48% significantly higher than that (77.38%）of the control group(P<0.05).Before and after treatment, there was no difference in MMSE scores between the two groups (P>0.05).After treatment, the score of TESS in the observation group was (8.34+2.71), and the score of TESS in the control group was (8.12+2.64) (P>0.05).
Conclusion  : The effect of sodium valproate combined with risperidone in the treatment of epileptic mental disorders is significant. It has little effect on cognitive function and light side effect. It is worth popularizing.