【摘要】

【摘要】目的 研究舍曲林治疗颅脑外伤后睡眠障碍伴抑郁患者的临床效果。
方法 纳入70例颅脑外伤后睡眠障碍伴抑郁患者作为研究对象，随机抽签分为观察组与对照组，每组35例。观察组给予舍曲林干预，对照组给予帕罗西汀治疗。采用匹兹堡睡眠质量指数（PSQI）和汉密顿抑郁量表（HAMD）比较两组治疗前后睡眠质量和抑郁状态，并采用神经行为认知状态测试量表（NCSE）记录治疗前后认知功能水平。
结果 两组治疗总体疗效差异无统计学意义（P ＞ 0.05）。两组治疗后PSQI和HAMD评分均显著低于入院时，差异有统计学意义（P ＜ 0.05），治疗后观察组PSQI和HAMD评分均显著低于对照组，差异有统计学意义（P ＜ 0.05）。观察组治疗后专注能力、理解能力、命名能力、结构能力、计算能力及判断推理能力等NCSE评分显著高于对照组和入院时评分，差异有统计学意义（P ＜ 0.05）。两组患者治疗前后定向能力、复述能力及类似性能力评分差异无统计学意义（P ＞ 0.05）。
结论 舍曲林治疗颅脑外伤后睡眠障碍和抑郁效果显著，且有助于改善认知功能，具有较高临床应用价值。

【Abstract】

【Abstract】Objective To study the effect of sertraline to treat the patients with sleep disorder with depression after craniocerebral trauma.
Methods 70 patients with sleep disorder and depression after craniocerebral trauma were as the research objects and were randomly divided into the observation group and the control group, 35 cases in each group.The observation group received sertraline, the control group received paroxetine.The sleep quality and depression were compared between the two groups before and after treatment by the pittsburgh sleep quality index (PSQI) and the hamilton depression scale (HAMD).The neurobehavioral cognitive status examination (NCSE) was used to record cognitive function before and after treatment.
Results There was no significant difference in the overall curative effect between the two groups (P > 0.05).The scores of PSQI and HAMD in the two groups after treatment were significantly lower than those at admission, the difference were statistically significant (P < 0.05).The scores of PSQI and HAMD in the observation group after treatment were significantly lower than those in the control group, the difference were statistically significant (P < 0.05).The NCSE scores of attention, understand, naming, structural ability, computational power and reasoning ability in the observation group after treatment were significantly higher than those in the control group and on admission,the difference were statistically significant (P < 0.05).There were no significant difference in the scores of orientating ability, retelling ability and similarity ability between the two groups before and after treatment (P > 0.05).
Conclusion   There is significant effect of sertraline to treat the sleep disorders and depression after craniocerebral trauma, and it can help to improve cognitive function and it has high clinical value.