【摘要】

【摘要】目的 研究老年痴呆患者认知障碍程度与抑郁症风险的相关性。
方法 纳入80例老年痴呆患者作为研究对象，分别采用蒙特利尔认知评估量表（MoCA）和汉密尔顿抑郁量表（HAMD）记录患者认知功能状态和抑郁水平，分析认知功能障碍程度与抑郁症的关系。
结果 80例患者HAMD评分（10.61±4.54）分；评分＞8分者31例（38.75%）。MoCA评分（20.05±7.62）分；评分≥26分（正常组）17例，评分＜26分者63例，其中轻度38例，中度17例，重度8例。不同程度认知功能障碍患者性别、年龄、文化程度及HDS评分差异无统计学意义（P ＞ 0.05）。四组患者HAMD评分差异有统计学统计学意义（P ＜ 0.05）。MoCA与HAMD评分呈显著负相关性（r = -0.581，P = 0.000）。ROC分析
结果显示MoCA评分判断抑郁症的AUC为0.767（β = 0.058，95%CL = 0.653-0.880，P = 0.000），敏感度为0.796，特异度为0.677，最佳截断值为22.5分。
结论 老年痴呆患者认知障碍与抑郁症关系密切，MoCA评分有助于预测抑郁症的发生。

【Abstract】

【Abstract】Objective To study the correlation between cognitive impairment and risk of depression in senile dementia patients.
Methods 80 elderly patients with dementia were included in the study. The cognitive function status and depression level were recorded by the montreal cognitive assessment scale (MoCA) and the hamilton depression scale (HAMD), the relationship between the degree of cognitive impairment and depression was analyzed.
Results The HAMD scores of 80 patients were (10.61 ± 4.54) was scored, the scores over 8 points were 31 cases (38.75%).The MoCA scores were (20.05 ± 7.62),the scores over 26 points were 17 cases (normal group).There were 63 cases with the scores over 26 points,38 cases were light, 17 cases were moderate, 8 cases were severe.There were no significant difference in gender, age, education level and the HDS score among patients with different degrees of cognitive impairment (P > 0.05).There was statistically significant difference of HAMD scores between the four groups (P < 0.05).There was significant negative correlation between MoCA and HAMD score (r = -0.581, P = 0.000).The results of ROC analysis showed that the AUC was 0.767 (β = 0.058, 95%CL = 0.653-0.880, P = 0.000),the sensitivity was 0.796 and the specificity was 0.677,the best truncation value was 22.5 points.
Conclusion   There was closely relevance between cognitive impairment and depression in patients with senile dementia. The MoCA score can help to predict the occurrence of depression.