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奥氮平联合氟西汀治疗抑郁症的疗效和不良反应分析

  • 凤燕琼,何怡发,张红霞,汤姿瑛,代龙,李嶔

* 通信作者: 凤燕琼, 单位:上海市民政第二精神卫生中心医务科 201319

摘要

【摘要】
目的:探讨奥氮平联合氟西汀治疗抑郁症的临床效果和不良反应情况。

方法:选取2013年1月-2015年1月本院住院治疗的抑郁症患者106例,随机分成对照组和观察组,对照组53例单纯给予氟西汀治疗,观察组53例给予奥氮平联合氟西汀治疗,共治疗8周。于治疗前及治疗后2、4、6、8周时用汉密顿抑郁量表( HAMD) 和汉密顿焦虑量表(HAMA) 分别对两组患者的抑郁和焦虑程度进行评分。对比分析两组患者的临床疗效及两组药物的不良反应情况。

结果:两组在治疗后2、4、6、8 周时 HAMD、HAMA评分均较基线值有明显降低,观察组在治疗后2、4、6、8周时HAMD、HAMA评分均低于对照组,差异有统计学意义(P<0.05);观察组对疾病的治愈率明显高于对照组,差异有统计学意义(P<0.05);观察组和对照组不良反应发生率分别为39. 6% 和56. 6% ,差异有统计学意义 ( P<0. 05) 。

结论:奥氮平联合氟西汀治疗抑郁症起效快、临床效果显著,且不良反应事件发生率低于单用氟西汀,值得临床推广。

关键词:【关键词】奥氮平;氟西汀;抑郁症;疗效;不良反应

ABSTRACT

【Abstract】
Objective: Explore the olanzapine combined fluoxetine treatment the clinical effect and adverse reaction of depression.

Methods: Selection in January 2013 - January 2015 in our hospital treated 106 cases of patients with depression and randomly divided into control group and observation group, Control group of 53 cases of pure given fluoxetine treatment, observation group 53 cases given olanzapine combined fluoxetine treatment, a total of eight weeks of treatment. In the before and after treatment for 2, 4, 6, 8 weeks with Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA) respectively on two groups of patients to rate of depression and anxiety. Comparison and analysis the clinical curative effect of two groups of patients and two groups of drug adverse reaction.

Results: In the two groups after treatment for 2, 4, 6, 8 weeks of HAMD, HAMA scores were significantly lower than the baseline value, observation group after treatment for 2, 4, 6, 8 weeks of HAMD, HAMA scores were lower than the control group, the difference was statistically significant (P < 0.05); The cure rate of disease observation group was obviously higher than that of control group, the difference was statistically significant (P < 0.05); Observation group and control group 39. The incidence of adverse reactions, respectively 6% and 56. 6%, the difference was statistically significant (P < 0. 05).

Conclusion  s: Olanzapine combined fluoxetine treatment of depression effect quickly, clinical effect is remarkable, and lower incidence of adverse events, with fluoxetine, worth clinical promotion.

Key words: 【Key words】Olanzapine; Fluoxetine; Depression; The curative effect; Adverse reactions.

引用本文 / How to Cite This Article

凤燕琼,何怡发,张红霞,汤姿瑛,代龙,李嶔.奥氮平联合氟西汀治疗抑郁症的疗效和不良反应分析[J]. 国际精神病学杂志, , (): -

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