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代谢综合征肺通气功能的变化及其相关因素探讨

  • 董玲,朱丽华,黄自碧,韦菊芳,王芃,甘敏,郑慧蕾,李薇,彭信言,黄玲,庾蓝玲,陈青云

* 通信作者: 陈青云, 单位:广西医科大学第一附属医院健康管理部 530021

摘要


目的:探讨代谢综合征及其组分对肺通气功能的影响。

方法:127例研究对象按照代谢异常个数被分为四组:无代谢异常为对照组,1个组分代谢异常为代谢异常1组,2个组分代谢异常为代谢异常2组,≥3个组分代谢异常为代谢异常3组即代谢综合征组。代谢综合征的诊断标准参照2013年中国2型糖尿病防治指南中的代谢综合征诊断标准。所有研究对象均测量腰围、体质指数、血压,检测血糖、肌酐、尿酸,检查肺功能以及超声检查有无颈动脉硬化、脂肪肝等,比较各组以上各项指标的差异,运用多因素分析评价代谢综合征与肺通气功能的关系。

结果:四组间VC%pred、FVC%pred、FEV1%pred、FEV1/FVC、MEF75%pred、MVV%pred存在统计学差异(P<0.05)。其中代谢异常3组VC%pred、FVC%pred、FEV1%pred、FEV1/FVC、MVV%pred显著低于对照组(P<0.05)。代谢异常3组VC%pred、FVC%pred、FEV1%pred、MEF75%pred、MVV%pred、显著低于代谢异常1组(P<0.05)。将代谢综合征各组分进入多元线性回归模型,随着腰围、收缩压升高,体质指数的下降,FVC%pred呈下降趋势,偏回归系数B和P值分别为(-0.534,0.011)、(-0.221,0.043)、(1.674,0.004)。随着体质指数下降、腰围的增加,FEV1%Pred呈下降趋势,B和P值分别为(1.185,0.034)、(-0.495,0.014)。

结论:代谢综合征患者肺通气功能较正常人下降,表现为混合性通气功能障碍,而且肺通气功能障碍主要与代谢综合征组分中的高血压、中心型肥胖有关。

关键词:代谢综合征;肺通气功能;腹型肥胖;高血压

ABSTRACT


Objective To investigate the effects of metabolic syndrome and its components on pulmonary ventilation function.

Methods 127 subjects were divided into four groups according to the number of abnormal metabolic disorders: no metabolic abnormalities as the control group, 1 component of metabolic abnormality in the metabolic abnormality group 1, 2 components in the metabolic abnormality group 2, and 3 and more than 3 components, the metabolic syndrome in the metabolic abnormality group 3. The diagnostic criteria of metabolic syndrome refer to the diagnostic criteria of metabolic syndrome in the Guideline for Prevention and Treatment of Type 2 Diabetes in China (2013 Edition). All subjects were checked blood pressure, waist circumference, height, weight, measured blood glucose, creatinine, uric acid, examined pulmonary function tests and examined ultrasound to show whether carotid atherosclerosis and fatty liver or not. The differences of all the indexes above each group were compared and the relationship between metabolic syndrome and pulmonary ventilation function evaluated by a multivariate analysis.

Results There were significant differences in VC%pred, FVC%pred, FEV1%pred, FEV1/FVC, MEF75%pred, and MVV%pred in the four groups (P<0.05). Among them, VC% pred, FVC% pred, FEV1%pred, FEV1/FVC and MVV%pred in the metabolic abnormality group 3, were significantly lower than those in the control group (P<0.05). VC%pred, FVC%pred, FEV1%pred, MEF75%pred and MVV%pred in the group 3 were significantly lower than those in the group 1(P<0.05). After the components of metabolic syndrome were put into a multiple regression model, as waist circumference and systolic blood pressure increased and body mass index decreased, FVC%pred showed a downward trend, and partial regression coefficients B and P were (-0.534, 0.011), (-0.221, 0.043), (1.674, 0.004), respectively. As body mass index decreased and waist circumference increased, FEV1%Pred showed a downward trend, in which B and P values were (1.185, 0.034) and (-0.495, 0.014) respectively.

Conclusion   The pulmonary ventilation function of patients with metabolic syndrome is lower than that of normal persons, which is characterized by mixed ventilation dysfunction. Moreover, the dysfunction of pulmonary ventilation is mainly related to blood pressure and central obesity of the components of the metabolic syndrome.

Key words: metabolic syndrome; pulmonary ventilation function;central obesity;hypertension

引用本文 / How to Cite This Article

董玲,朱丽华,黄自碧,韦菊芳,王芃,甘敏,郑慧蕾,李薇,彭信言,黄玲,庾蓝玲,陈青云.代谢综合征肺通气功能的变化及其相关因素探讨[J]. 国际精神病学杂志, , (): -

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