【摘要】

【摘要】目的 研究舍曲林治疗脑胶质瘤术后睡眠障碍伴抑郁患者的临床效果。
方法 纳入70例脑胶质瘤术后睡眠障碍伴抑郁患者作为研究对象，随机抽签分为两组，每组35例。观察组给予舍曲林干预，对照组给予帕罗西汀治疗。比较两组治疗前后睡眠质量和抑郁状态，并记录治疗前后认知功能水平。
结果 两组治疗总体疗效差异无统计学意义（P ＞ 0.05）。两组治疗后PSQI和HAMD评分均显著低于入院时，差异有统计学意义（P ＜ 0.05），治疗后观察组PSQI和HAMD评分均显著低于对照组，差异有统计学意义（P ＜ 0.05）。观察组治疗第4周和治疗后NCSE评分显著高于对照组和入院时评分，差异有统计学意义（P ＜ 0.05）。
结论 舍曲林治疗脑胶质瘤术后睡眠障碍和抑郁效果显著，且有助于改善认知功能，具有较高临床应用价值。

【Abstract】

【Abstract】Objective To study the effect of sertraline to treat the patients with sleep disorder with depression after brain glioma operation.
Methods 70 patients with sleep disorder and depression after brain glioma operation were as the research objects and were randomly divided into two groups, 35 cases in each group.The observation group received sertraline, the control group received paroxetine.The sleep quality and depression were compared between the two groups before and after treatment,the cognitive function before and after treatment was recorded.
Results There was no significant difference in the overall curative effect between the two groups (P > 0.05).The scores of PSQI and HAMD in the two groups after treatment were significantly lower than those at admission, the difference were statistically significant (P < 0.05).The scores of PSQI and HAMD in the observation group after treatment were significantly lower than those in the control group, the difference were statistically significant (P < 0.05).The NCSE scores in the observation group at fourth week of treatment and after treatment were significantly higher than those in the control group and on admission,the difference were statistically significant (P < 0.05).
Conclusion   There is significant effect of sertraline to treat the sleep disorders and depression after brain glioma operation, and it can help to improve cognitive function and it has high clinical value.