【摘要】

[摘要] 目的 分析血管性痴呆（VD）采用清脑益智方联合丁苯酞软胶囊治疗对患者认知功能及血清血管内皮生长因子（VEGF）、脑源性神经营养因子（BDNF）的影响。
方法 选取2014年4月～2017年5月我院收治的86例VD患者，随机分组进行对照研究，对照组（n=43）予以常规药物和丁苯酞软胶囊治疗，观察组（n=43）在对照组基础上加用清脑益智方治疗，对比两组总有效率、简易智力状态检查量表（MMSE）评分、生活质量评价量表（QOL）评分、氧化应激指标[丙二醛（MDA）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH-Px）、超氧化物歧化酶（SOD）]、血清脑源性神经营养因子（BDNF）、血管内皮功能指标[血管内皮生一氧化氮（NO）、长因子（VEGF）、内皮素（ET-1）]、血液流变学指标[红细胞比容（Hct）、红细胞聚集指数（RBC）、全血高切黏度（BVH）、全血低切黏度（BVL）]水平。
结果 观察组总有效率90.70%高于对照组69.77%（P＜0.05）；两组治疗后MDA均低于治疗前，CAT、GSH-Px、SOD、BDNF均高于治疗前，且观察组改善程度大于对照组（P＜0.05）；观察组治疗后NO、VEGF、MMSE评分高于对照组，ET-1低于对照组（P＜0.05）；观察组治疗后Hct、RBC、BVH、BVL低于对照组，QOL评分高于对照组（P＜0.05）。
结论 VD采用清脑益智方联合丁苯酞软胶囊治疗，可改善患者认知功能与氧化应激状态，降低血流黏稠度，提高患者生活质量，疗效显著。

【Abstract】

[Abstract] Objective To analyze the effects of Qingnao Yizhi Decoction combined with Dingbenqi Soft Capsule on cognitive function and serum vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF) in patients with vascular dementia (VD).
Methods Eighty-four patients with VD admitted to our hospital from April 2014 to May 2017 were randomly selected for control study. The control group (n=43) was treated with conventional drugs and butylphthalide soft capsules. On the basis of the control group, the treatment of Qingnao Yizhi Recipe was used in the observation group (n=43) to compare the total effective rate, the Simple Intelligence State Examination Scale (MMSE) score, the Quality of Life Assessment Scale (QOL) score, and the oxidative stress index [C Aldehyde (MDA), catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), serum brain-derived neurotrophic factor (BDNF), vascular endothelium Functional indicators [vascular endothelial nitric oxide (NO), long-factor (VEGF), endothelin (ET-1)], hemorheology index [erythrocyte specific volume (Hct), erythrocyte aggregation index (RBC), whole blood High cut viscosity (BVH), whole blood low cut viscosity (BVL) level.
Results The total effective rate of the observation group was 90.70% higher than that of the control group (69.77%) (P<0.05). The MDA of the two groups was lower than that before treatment. The CAT, GSH-Px, SOD and BDNF were higher than that before treatment, and the observation group improved. The degree of NO, VEGF and MMSE in the observation group was higher than that in the control group, and the ET-1 was lower than that in the control group (P<0.05). The Hct, RBC, BVH and BVL were low in the observation group after treatment. In the control group, the QOL score was higher than that of the control group (P<0.05).
Conclusion   VD is treated with Qingnao Yizhi Decoction combined with butylphthalide soft capsule, which can improve the cognitive function and oxidative stress, reduce blood flow viscosity and improve the quality of life of patients.