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MRI判断高血压合并糖尿病患者脑小血管病变的临床价值

  • 王志鹏

* 通信作者: 王志鹏, 单位:秦皇岛军工医院 066000

摘要

摘要
目的:研究磁共振(MRI)判断高血压合并糖尿病患者脑小血管病变的临床价值。

方法:回顾性分析本院120例脑小血管病变患者临床资料,根据是否合并基础疾病分为四组,分别为无基础疾病组(A组,18例)、高血压组(B组,31例)、糖尿病组(C组,37例)及高血压合并糖尿病组(D组,34例)。记录脑小血管病变MRI征象,比较四组患者MRI影像检查

结果指标,分析MRI检查

结果与认知功能的关系。

结果:四组患者腔隙性梗死和脑室周围脑白质疏松病灶发生率差异有统计学意义(P < 0.05)。四组患者腔隙性梗死和脑室周围脑白质疏松严重程度差异有统计学意义,其中D组严重程度显著重于A、B、C三组,差异有统计学意义(P < 0.05)。四组患者脑微出血发生率差异有统计学意义(P < 0.05),四组患者脑出血严重程度差异有统计学意义,其中B、C两组严重程度显著重于A组(P < 0.05)。四组患者MoCA和额叶区FA值水平差异有统计学意义(P < 0.05),MoCA与额叶FA呈显著正相关性(r = 0.725,P = 0.000),MoCA评分与额叶ADC呈负相关(r = -0.579,P = 0.000)。

结论:糖尿病和高血压加重脑小血管病变,MRI检查有助于判断病情严重程度,为临床个体化治疗提供量化资料依据。

关键词:关键词 高血压合并糖尿病;脑小血管病变;MRI

ABSTRACT

[Abstract]
Objective: To study the clinical value of MRI in judging cerebral small vessel disease in patients with hypertension and diabetes mellitus.

Methods: The clinical dataes of 120 patients with cerebral small vessel disease were retrospectively analyzed,they were divided into four groups,which accorded to the basic diseases.The no basic disease group (group A, 18 cases), hypertension group (group B, 31 cases), diabetes group (group C, 37 cases) and hypertension complicated with diabetes group (group D, 34 cases).The MRI signs of cerebral small vessel disease were recorded, and the MRI indexes were compared between the four groups.The relationship between MRI indexes and cognitive function was analyzed.

Results: There were significant differences in the incidence of lacunar infarction and leukoaraiosis around the ventricles of the brain between the four groups (P < 0.05).There were significant difference in the severity of lacunar infarction and leukoaraiosis around the ventricles of the brain between the four groups,the severity of group D was significantly heavier than the three groups of A, B and C,the differences were statistically significant (P < 0.05).There was significant difference in the incidence of cerebral microbleeds between the four groups,the severity of B and C two groups were significantly higher than that of group A (P < 0.05).There were significant difference between the four groups of MoCA and FA in frontal lobe (P < .05).There was positive correlation between MoCA and frontal lobe FA (r = 0.725, P = 0.000), there was negative correlation between MoCA score and frontal ADC (r = -0.579, P = 0.000).

Conclusion  : The diabetes and hypertension aggravate the small vascular lesions of the brain. MRI examination is helpful to judge the severity of the disease and provide the quantitative data basis for the clinical individualized treatment.

Key words: [Keywords] hypertension complicated with diabetes mellitus; cerebral small vessel disease; MRI

引用本文 / How to Cite This Article

王志鹏.MRI判断高血压合并糖尿病患者脑小血管病变的临床价值[J]. 国际精神病学杂志, , (): -

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