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奥氮平联合氟西汀治疗抑郁症的有效性和安全性研究

  • 邓花

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摘要


目的探讨奥氮平联合氟西汀治疗抑郁症的有效性和安全性。

方法选取2011年2月到2014年2月接受治疗的抑郁症患者98例,随机分成联合组和对照组,联合组49例给予奥氮平联合氟西汀治疗,对照组49例给予氟西汀治疗。两组均治疗8周,在治疗4、6、8周时对两组患者的抑郁和焦虑程度进行一次评定,用汉密顿抑郁量表(HAMD)评定患者的抑郁程度,用汉密顿焦虑量表(HAMA)评定患者的焦虑程度。观察两组患者的临床疗效和药物起效时间,以及两种药物的不良反应,分析两种药物的用药安全性。

结果联合组对疾病的有效率明显高于对照组。两组在治疗后4、6、8周时HAMD评分均较基线值有明显降低,联合组在治疗后4、6、8周时HAMD评分均低于对照组,差异有统计学意义(P<0.05)。联合组和对照组不良反应发生率分别为42.8%和57.1%,差异无统计学意义(P>0.05)。

结论奥氮平联合氟西汀治疗抑郁症临床效果显著,安全性高、起效快,不良反应与单一采用氟西汀治疗相差不大,可耐受。

关键词:奥氮平;氟西汀;抑郁症;有效性;安全性

ABSTRACT


Objective: To evaluate the study of olanzapine and fluoxetine in the treatment of refractory depression efficacy and safety.

Methods: from 2011February to 2014 February in our hospital 98 patients with refractory depression, with divided into combined group and control group two group, combined group 49 cases were treated with olanzapine combined with fluoxetine in the treatment of 49 cases in the control group, patients were given fluoxetine treatment. Two groups of patients treated at the same time 8 weeks, each group of two patients in the treatment of 4, 6, 8 weeks in two groups of patients for a rating, with Hamilton Depression Scale (HAMD) assess depression patients, the Hamilton Anxiety Scale (HAMA) assessment in patients with anxiety. To observe the clinical curative effect and drug effect of the two groups of patients in time, and the adverse reactions of two drugs, analysis of drug safety of two kinds of drugs.

Results: in the treatment group, the disease rate was significantly higher than the control group. In the two groups after treatment for 4 weeks, 6 weeks, and 8 weeks of HAMD 17 scores from baseline were significantly reduced, the United Group at 4 weeks after treatment, 6 weeks and 8 weeks, the HAMD17 scores were lower than the control group, the difference was statistically significant (P< 0.05). The combined group and the control group took the adverse reaction rate were 42.8% and 57.1%, the difference was not statistically significant (P > 0.05).

Conclusion  : olanzapine combined with fluoxetine in the treatment of refractory depression significant clinical effect, high safety, quick effect, adverse reaction and single fluoxetine in the treatment of difference, can be tolerated.

Key words: Olanzapine; Fluoxetine;Refractory depression; Efficacy; Safety;

引用本文 / How to Cite This Article

邓花.奥氮平联合氟西汀治疗抑郁症的有效性和安全性研究[J]. 国际精神病学杂志, 2015, 42(2): 18-20

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