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双相情感障碍并发代谢综合征患者认知功能损害的相关因素研究

  • 焦秀娟,徐东

* 通信作者: 焦秀娟, 单位:郑州市第八人民医院精神科 450000

摘要

【摘要】
目的 探讨影响双相情感障碍并发代谢综合征患者认知功能损害的相关因素。

方法 选取2015年6月到2018年6月于我院治疗的双相情感障碍患者188例作为实验组,其中实验组包括双相情感障碍并发代谢综合征患者98例(并发组)和不并发代谢综合征的双相情感障碍患者90例(不并发组);另外选取同时期于我院进行体检的健康受试者90例作为对照组,统计实验组患者的临床资料,并进行单因素方差分析;对实验组和对照组分别采取韦氏康星卡片分类测试(WCST)、连线测试(分为A、B两种)、数字广度测试(顺背、倒背、总分)、视觉再生测试、数字符号测试等测试受试者的认知功能;运用多元线性逐步回归分析,从而确定影响双相情感障碍并发代谢综合征患者认知功能损害的相关因素[1]。

结果 通过统计实验组患者(并发组和不并发组)的临床资料,并对

结果进行单因素方差分析,可以发现,并发组与不并发组在体质指数、运动量、糖化血红蛋白、空腹血糖、胰岛素、家族糖尿病史等方面的临床资料的差异具有统计学意义(P<0.05);而在发病年龄、是否吸烟、是否饮酒、家族高血压史和高血脂史等方面的临床资料的差异不具有统计学意义(P>0.05)。通过比较两组受试者的认知功能测试

结果可知,韦氏康星卡片分类测试、数字广度测试的倒背评分、视觉再生测试评分、数字符号测试评分的差异均具有统计学意义(P<0.05);而连线测试的时间、数字广度测试的顺背评分的差异不具有统计学意义(P>0.05)。通过对双相情感障碍并发代谢综合征患者认知功能损害相关因素的Logistic 回归分析可知,体质指数、运动量、糖化血红蛋白、病程、家族糖尿病史、受教育年限是导致双相情感障碍并发代谢综合征认知功能损害发生的独立影响因素(P<0.05)。

结论 双相情感障碍并发代谢综合征患者认知功能损害相对于不并发代谢综合征的双相情感障碍患者更加严重,且认知功能的损害受多种因素影响,本次研究为双相情感障碍并发代谢综合征患者的认知功能损害提供了一定临床依据,有利于早期的防治[2]。

关键词:【关键词】双相情感障碍;代谢综合征;认知功能;相关因素

ABSTRACT

[ Abstract ]
Objective To explore the related factors affecting cognitive impairment in patients with bipolar affective disorder complicated with metabolic syndrome.

Methods 188 patients with bipolar affective disorder who were treated in our hospital from June 2015 to June 2018 were selected as the experimental group. The experimental group included 98 patients with bipolar affective disorder complicated with metabolic syndrome (concurrent group) and 90 patients with bipolar affective disorder without metabolic syndrome (concurrent group); the other group was selected from me at the same time. Ninety healthy subjects who underwent physical examination in our hospital were taken as the control group. The clinical data of the experimental group were counted and analyzed by one-way ANOVA. The experimental group and the control group were tested by Wesconsin Card Classification Test (WCST), Wiring Test (A, B), Digital Width Test (Backward, Backward, Total Score), and Vision, respectively. Cognitive function of subjects was tested by sensory regeneration test and digital symbol test. Multivariate linear stepwise regression analysis was used to determine the related factors affecting cognitive function impairment in patients with bipolar affective disorder complicated with metabolic syndrome.

Results The clinical data of the experimental group (concurrent group and non-concurrent group) were analyzed by one-way ANOVA. It was found that there were significant differences between the concurrent group and non-concurrent group in body mass index, exercise volume, glycosylated hemoglobin, fasting blood sugar, insulin and family history of diabetes. There was no significant difference in age of onset, smoking, alcohol consumption, family history of hypertension and hyperlipidemia(P>0.05). Comparing the results of cognitive function test between the two groups, we can see that there are significant differences in Wesconsin card classification test, backward score of digital breadth test, visual regeneration test score and digital symbol test score (P<0.05); while there are no differences in the time of connection test and backward score of digital breadth test (P<0.05). It was statistically significant (P>0.05). Logistic regression analysis showed that body mass index, exercise volume, glycosylated hemoglobin, course of disease, family history of diabetes mellitus and years of education were independent influencing factors of cognitive impairment in patients with bipolar affective disorder complicated with metabolic syndrome(P<0.05).

Conclusion   The cognitive impairment of bipolar affective disorder patients complicated with metabolic syndrome is more serious than that of patients without metabolic syndrome, and the impairment of cognitive function is affected by many factors. This study provides a certain clinical basis for cognitive impairment of bipolar affective disorder patients complicated with metabolic syndrome. It is conducive to early prevention and treatment.

Key words: [Keywords] bipolar disorder; metabolic syndrome; cognitive function; related factors.

引用本文 / How to Cite This Article

焦秀娟,徐东.双相情感障碍并发代谢综合征患者认知功能损害的相关因素研究[J]. 国际精神病学杂志, , (): -

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