【摘要】

【摘要】 目的 探讨慢性睡眠障碍患者血清中S100B、神经特异性烯醇化酶（NSE）和脑源性神经营养因子（BDNF）水平的表达及与PSQI评分的相关性。
方法 选取2015年2月至2017年2月来我院进行治疗慢性睡眠障碍患者120例作为CID组，选择同一时间来我院进行体检的健康者50例作为对照组。检测并比较两组患者血清S100B、NSE、BDNF，并使用PSQI评分评价两组患者睡眠质量。使用Spearman相关系数分析法分析血清S100B、NSE、BDNF与PSQI评分的相关性。使用Logistic回归分析法分析血清S100B、NSE、BDNF与睡眠质量间的关系。
结果 CID患者血清S100B和NSE水平显著高于对照组受试者（P<0.05），但BDNF水平显著低于对照组受试者（P<0.05）。CID组S100B水平、NSE水平与PSQI评分之间呈现正相关（P<0.05），而BDNF水平与PSQI评分之间呈现负相关（P<0.05）。单因素分析
结果显示高的S100B、NSE水平和低的BDNF水平是CID的影响因素（P<0.05）。影响患者PSQI得分的和独立危险因素为S100B水平、NSE水平和BDNF水平（P<0.05）。
结论 慢性睡眠障碍患者血清中S100B和NSE水平升高而BDNF水平下降，提示存在神经系统损伤，三者水平与患者PSQI得分存在相关性，是患者睡眠质量的独立危险因素。

【Abstract】

[Abstract] Objective To investigate the expression of S100B, NSE and BDNF in serum of patients with chronic insomnia disorder and its correlation with PSQI score.
Methods: From February 2015 to February 2017, 120 patients with chronic sleep disorders were enrolled in our hospital as the CID group, and 50 healthy subjects were selected as the control group. The serum levels of S100B, NSE and BDNF were detected and compared between the two groups, and the sleep quality of the two groups was evaluated using the PSQI score. Correlation between serum S100B, NSE, BDNF and PSQI scores was analyzed using Spearman correlation coefficient analysis. Logistic regression analysis was used to analyze the relationship between serum S100B, NSE, BDNF and sleep quality.
Results: Serum S100B and NSE levels were significantly higher in CID patients than in control subjects (P<0.05), but BDNF levels were significantly lower than control subjects (P<0.05). There was a positive correlation between S100B level, NSE level and PSQI score in CID group (P<0.05), while there was a negative correlation between BDNF level and PSQI score (P<0.05). Univariate analysis showed that high S100B, NSE levels and low BDNF levels were the influencing factors of CID (P<0.05). The independent risk factors affecting the PSQI score of patients were S100B level, NSE level and BDNF level (P<0.05).
Conclusion  : The serum level of S100B and NSE and the level of BDNF in the patients with chronic insomnia disorders are increased, suggesting that there is neurological impairment. The levels of these three levels are correlated with the patients' PSQI scores and are independent risk factors for the quality of sleep.