【摘要】

  【摘要】目的 观察多奈哌齐联合喹硫平对阿尔茨海默病患者认知功能和精神症状的改善作用。
方法 选取本院2011年7月―2018年7月收治的100例阿尔茨海默病患者，按随机数表法分为实验组与对照组。两组均有因药物不良反应或失访而脱落的病例，最终实验组48例入组、对照组47例入组。实验组采用多奈哌齐联合喹硫平进行治疗，对照组采用多奈哌齐联合奥氮平进行治疗，两组均治疗12周。采用MMSE量表于治疗前、治疗12周后评估两组认知功能，采用痴呆病理行为评定量表（BEHAVE-AD）于治疗前、治疗12周后评估两组精神症状。比较两组治疗期间不良反应总发生率。
结果 两组治疗12周后的MMSE评分均较治疗前升高、BEHAVE-AD评分较治疗前降低（P<0.05）。观察组治疗12周后的BEHAVE-AD评分、MMSE评分与对照组比较差异无统计学意义（P>0.05）。实验组不良反应总发生率20.83%，低于对照组40.43%（P<0.05）。
结论 多奈哌齐联合喹硫平与多奈哌齐联合奥氮平均可改善阿尔茨海默病患者认知功能与精神症状，其中多奈哌齐联合喹硫平对患者睡眠、呼吸功能的影响更轻，具有更高安全性，可优先选择。

【Abstract】

[Abstract] Objective To observe the effect of donepezil combined with quetiapine on cognitive function and psychiatric symptoms in patients with Alzheimer's disease.
Methods A total of 100 patients with Alzheimer's disease who were admitted to our hospital from July 2011 to July 2018 were randomly divided into experimental group and control group. There were cases in which both groups fell off due to adverse drug reactions or loss of follow-up. In the final experimental group, 48 patients were enrolled and 47 patients in the control group were enrolled. The experimental group was treated with donepezil plus quetiapine, and the control group was treated with donepezil plus olanzapine. Both groups were treated for 12 weeks. The cognitive function was evaluated by Mini-mental State Examination before treatment and after 12 weeks of treatment. The psychotic symptoms of the two groups were evaluated before and 12 weeks after treatment with the Behavioralpathology Alzheimer’ sdisease. The overall incidence of adverse reactions during the two treatment periods was compared between two groups.
Results The MMSE scores of the two groups after 12 weeks of treatment were higher than those before treatment, and the BEHAVE-AD score was lower than that before treatment (P<0.05). There was no significant difference in BEHAVE-AD score and MMSE score between the observation group and the control group after 12 weeks of treatment (P>0.05). The total incidence of adverse reactions in the experimental group was 20.83%, which was lower than 40.43% in the control group(P<0.05).
Conclusion   Donepezil combined with quetiapine and donepezil combined with olanzapine can improve cognitive function and psychiatric symptoms. Among them, donepezil combined with quetiapine has less impact on sleep and respiratory function, and has higher safety.