【摘要】

【摘要】目的 探讨抑郁症患者对负性情绪面孔的注意偏向及大脑对情绪信息加工时存在的偏侧化效应。
方法 抑郁症组（MDD）31名被试和健康对照组（HC）28名被试进行点探测范式实验，同时记录实验过程中的事件相关电位（ERP）。
结果 通过呈现负性情绪面孔和中性情绪面孔诱发的N170分析，MDD组和HC组在未表现出对负性刺激注意偏向。在加工情绪面孔时，MDD组大脑O1区域产生的N170波幅明显小于O2区域；而在HC组中没有表现出这种大脑偏侧化。MDD组和HC组进行比较，在O1区域MDD组的N170波幅明显小于HC组，两组人群在O2区域产生的N170波幅无明显差异。
结论 在对面孔刺激加工时抑郁症患者左右大脑的认知能力不同，导致产生的脑电信号存在很大的波幅差异，为今后的临床诊断提供更有价值的参考指标。

【Abstract】

【Abstract】Objective To explore the attention bias of depressive patients toward negative emotional faces and the lateralization effect of brain on emotional information processing.
Methods 31 subjects in depression group (MDD) and 28 subjects in healthy control group (HC) were tested by dot-probe task. Event-related potentials (ERP) were recorded during the experiment.
Results By the analysis of N170 induced by negative emotional faces and neutral emotional faces, MDD and HC groups showed no attention bias to negative stimuli. The amplitude of N170 produced at the O1 region of the brain at the MDD group was significantly smaller than that in the O2 region; this cerebral lateralization was not observed in the HC group. Compared with HC group and MDD group, the N170 amplitude of MDD group was significantly smaller than that of HC group at the O1 region, and there was no significant difference in N170 amplitude between the two groups at the O2 region.
Conclusion   When facial stimulation is processed, the cognitive abilities of the left and right brains of depressive patients are different, which results in great amplitude difference of EEG signals, and provides more valuable reference indexes for clinical diagnosis in the future.