【摘要】

【摘要】目的 探讨多奈哌齐与法舒地尔联合心理疏导对血管性认知障碍（VCI）患者负性情绪及血清炎性因子水平的影响。
方法 选取68例VCI患者随机分为观察组与对照组，各34例。对照组应用多奈哌齐治疗和心理疏导，观察组在对照组基础上加用法舒地尔。比较两组治疗前后简易精神状态检查量表（MMSE）、Barthel指数（BI）、汉密尔顿焦虑量表（HAMA）和汉密尔顿抑郁量表（HAMD）评分，检测血清超敏C反应蛋白（hs-CRP）、白介素-6（IL-6）和肿瘤坏死因子α（TNF-α）水平。
结果 观察组治疗后MMSE、BI评分显著高于对照组，HAMA、HAMD评分显著低于对照组（P<0.05）；观察组治疗后血清hs-CRP、IL-6及TNF-α水平显著低于对照组（P<0.05）。
结论 多奈哌齐与法舒地尔联合心理疏导有利于改善VCI患者的认知功能与日常生活活动能力，减轻负性情绪，并可下调促炎因子水平。 【关键词】血管性认知障碍；多奈哌齐；法舒地尔；心理疏导；负性情绪；炎性因子

【Abstract】

【Abstract】 Objective To investigate the effects of donepezil and fasudil combined with psychological counseling on negative emotion and serum inflammatory factors in patients with vascular cognitive impairment (VCI).
Methods 68 patients with VCI were randomly divided into observation group and control group, 34 cases in each group. The control group was treated with donepezil and psychological counseling, and the observation group was given fasudil on the basis of the control group. The Mini-Mental State Examination Scale (MMSE), Barthel Index (BI), Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) before and after treatment were evaluated, the serum levels of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor-α(TNF-α) were compared.
Results The MMSE and BI scores in the observation group were significantly higher than those in the control group,the HAMA and HAMD scores were significantly lower than those in the control group (P<0.05). The serum levels of hs-CRP, IL-6 and TNF-α in the observation group were significantly lower than those in the control group (P<0.05).
Conclusion   The donepezil and fasudil combined with psychological counseling is beneficial to improve the cognitive function and activities of daily living in patients with VCI, which can reduce the negative emotions, and down-regulate the levels of pro-inflammatory factors. 【Key words】 Vascular cognitive impairment; Donepezil; Fasudil; Psychological counseling; Negative emotion;Inflammatory factor