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长期服用奥氮平患者的肝脏超声特点及相关因素分析

  • 冯薇

* 通信作者: 冯薇, 单位:鹤壁市人民医院超声科

摘要


目的:分析长期服用奥氮平患者的肝脏超声特点及相关因素。

方法:选取2016年6月-2019年2月期间我院治疗的152例精神分裂症患者进行回顾分析,根据服用奥氮平的时间分为短期组(持续服药≤6个月)和长期组(持续服药≥2年),每组76例,对比两组患者的肝脏超声特点,应用单因素和多因素Logistic回归模型分析肝脏超声特点的影响因素。

结果:长期组胆囊结石、肝内胆管结石、脂肪肝的发生率明显高于短期组,但两组患者胆囊炎、肝弥漫性损害的发生率无统计学差异(P>0.05);单因素Logistic回归分析显示,胆囊结石、肝内胆管结石、脂肪肝为肝脏超声异常的相关因素,而胆囊炎、肝弥漫性损害与肝脏超声异常无明显的相关性;多因素Logistic回归分析显示,胆囊结石、肝内胆管结石、脂肪肝为肝脏超声异常独立危险因素。

结论:长期服用奥氮平易导致患者出现药源性的肝脏损害,且胆囊结石、肝内胆管结石、脂肪肝为肝脏超声异常的独立危险因素。

关键词:奥氮平;肝脏超声特点;精神分裂症;相关因素分析

ABSTRACT


Objective To analysis of liver ultrasound characteristics and related factors in patients taking long-term olanzapine.

Methods A retrospective analysis of 152 patients with schizophrenia treated in our hospital from June 2016 to February 2019 was conducted. The time of taking olanzapine was divided into short-term group (Continuous medication≤6 months)and long-term group(Continuous medication≥2 years), 76 cases in each group.To compare the characteristics of liver ultrasound in the two groups, and to analyze the influencing factors of liver ultrasound characteristics by univariate and multivariate logistic regression models.Resules The incidence of gallbladder stones, intrahepatic bile duct stones and fatty liver in the long-term group was significantly higher than that in the short-term group, but there was no significant difference in the incidence of cholecystitis and diffuse liver injury between the two groups (P>0.05).Univariate logistic regression analysis showed that gallstones, intrahepatic bile duct stones, and fatty liver were related factors of liver ultrasound abnormalities, but there was no significant correlation between cholecystitis, diffuse liver damage and liver ultrasound abnormalities.Multivariate logistic regression analysis showed that gallstones, intrahepatic bile duct stones, and fatty liver were independent risk factors for liver ultrasound abnormalities.

Conclusion   Long-term use of olanzapine may lead to drug-induced liver damage in patients, and gallstones, intrahepatic bile duct stones, and fatty liver are independent risk factors for liver ultrasound abnormalities.

Key words: Olanzapine; Ultrasound characteristics of liver; Schizophrenia; Related factors analysis

引用本文 / How to Cite This Article

冯薇.长期服用奥氮平患者的肝脏超声特点及相关因素分析[J]. 国际精神病学杂志, 2019, 46(3): 467-469

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