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奥氮平过量临床特征及治疗

  • 邓茂林,邓湘辉

* 通信作者: 邓茂林, 单位:长沙市中心医院 410004

摘要


目的 探讨奥氮平过量临床特征及治疗。

方法 对2010年1月—2015年12月收治并随访服用奥氮平超过20mg/天42例患者的临床特征进行回顾性研究,总结奥氮平过量的临床特征及相关治疗、预后。

结果 奥氮平剂量250mg/天以下(28例),出现常见不良反应:锥体外系表现(15例),焦虑(26例), 血糖升高(12例)等;奥氮平剂量250mg/天以上(14例),出现严重不良反应:意识障碍(12例),呼吸抑制(10例),低血压(8例),继发多发脑梗死(3例),凝血机制异常(8例),肌溶解(2例),多脏器功能衰竭(合并肝、肾、凝血、呼吸、循环功能)(8例)。死亡病例(4例)。抢救成功患者(10例)均早期行血液灌流治疗。

结论 服用奥氮平剂量250mg/天以上者易出现严重并发症,甚至死亡,应尽早行血液灌流治疗。

关键词:奥氮平 不良反应 血液灌流

ABSTRACT


Objective To investigate Clinical Features and Treatment of Olanzapine Overdose.

Methods Clinical date of 42 patients taking Olanzapine Overdose from January 2010 to Decmber 2015 were analyzed retrospectively. Clinical features and cure were summarized.

Results Patients(28 cases) taking Olanzapine(<250mg/d) had some common adverse reactions, such as External pyramidal manifestations(15 cases),anxious(26 cases),hyperglycaemia(12 cases); Patients(14 cases) taking Olanzapine(>250mg/d) had serious adverse reactions, such as disorder of consciousness(12 cases),dyspnea(10 cases),hypopoesia(8 cases),multiple cerebral infarction(3 cases),abnormal coagulation mechanisim(8 cases),rhabdomyolysis(2 cases),Multiple organ failure(8 cases).Death cases(4 cases).Rescue patients(10 cases) were given blood perfusion therapy as early as possible.

Conclusion   Patients taking Olanzapine(>250mg/d) have serious adverse reactions,such as death,and should be given blood perfusion therapy as early as possible.

Key words: Olanzapine Adverse reactions Blood perfusion therapy

引用本文 / How to Cite This Article

邓茂林,邓湘辉.奥氮平过量临床特征及治疗[J]. 国际精神病学杂志, 2016, 43(3): 440-441

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