【摘要】

目的 分析脑卒中后癫痫患者应用左乙拉西坦联合丙戊酸钠治疗后疗效。
方法 采用随机数字表法将我院85例脑卒中后癫痫患者分组，对照组42例给予丙戊酸钠口服治疗，观察组43例联合左乙拉西坦治疗，对比两组患者治疗后血清炎性因子水平、癫痫症状改变、临床疗效及不良事件发生率。
结果 观察组治疗后癫痫发作次数、持续时间及IL-6、IL-2、TNF-α、NSE、痫样放电、累及导联数水平均低于对照组，总有效率高于对照组（P<0.05），不良反应发生率低于对照组（P>0.05）。
结论 左乙拉西坦联合丙戊酸钠能够有效减少脑卒中后癫痫患者癫痫发作次数及时间，其机制与阻断神经元异常放电，抑制血清炎症因子水平有关。

【Abstract】

Objective To analyze the efficacy of levetiracetam combined with sodium valproate in patients with epilepsy after stroke.
Methods Eighty-five patients with post-stroke epilepsy were enrolled in our hospital by random number table method. 42 patients in the control group were treated with sodium valproate orally, and 43 patients in the observation group were treated with levetiracetam. Sex factor levels, changes in epilepsy symptoms, clinical outcomes, and incidence of adverse events.
Results The number and duration of seizures and the levels of IL-6, IL-2, TNF-α, NSE, epileptiform discharge and lead in the observation group were lower than those in the control group, and the total effective rate was higher than that of the control group. <0.05), the incidence of adverse reactions was lower than that of the control group (P>0.05).
Conclusion   Levetiracetam combined with sodium valproate can effectively reduce the number and timing of seizures in patients with post-stroke epilepsy. The mechanism is related to the abnormal discharge of neurons and the inhibition of serum inflammatory factors.