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奥氮平联合氨磺必利治疗精神分裂症的效果及对睡眠和认知功能的影响

  • 张志勇

* 通信作者: 张志勇, 单位:新乡医学院第二附属医院

摘要


目的 探讨奥氮平联合氨磺必利治疗精神分裂症的效果及对睡眠和认知功能的影响。

方法 依据随机对照原则将2018年1月~2019年1月我院进行治疗的80例首发精神分裂症患者分为每组40例,对照组接受奥氮平治疗,观察组接受奥氮平联合氨磺必利治疗。比较两组治疗效果及安全性。

结果 观察组患者疗程结束时治疗总有效率高于对照组,差异显著(P<0.05);观察组患者疗程结束时蒙特利尔认知评估量表(MoCA)评分、简易精神状态评价量表(MMSE)评分均高于对照组,阳性和阴性症状量表(PANSS)评分均低于对照组,差异显著(P<0.05);观察组患者疗程结束时总睡眠时间、睡眠效率均高于对照组,睡眠潜伏期均低于对照组,差异显著(P<0.05);观察组患者疗程结束时心理社会评分、动力和精力评分、症状和不良反应评分均低于对照组,差异显著(P<0.05);两组患者药物相关不良反应总发生率并无统计学差异(P>0.05)。

结论 奥氮平联合氨磺必利治疗精神分裂症疗效显著,可明显改善患者睡眠质量、认知功能和生活质量,值得临床推荐。

关键词:精神分裂症;奥氮平;氨磺必利;睡眠质量;认知功能

ABSTRACT


Objective To explore the clinical effects and influence of sleep quality, cognitive function in patients with schizophrenia by olanzapine with amisulpride.

Methods 80 cases of patients with schizophrenia from 2018/01 to 2019/01 were randomly divided into observation group(40 cases) and control group(40 cases). The control group were treated by olanzapine. The observation group were treated by olanzapine with amisulpride. The clinical effect and safety were observed.

Results The total effective rate of the observation group at the end of the course was higher than the control group(P<0.05); The scores of MoCA and MMSE for the observation group at the end of the course were higher than the control group(P<0.05); The score of PANSS for the observation group at the end of the course was lower than the control group(P<0.05); The total sleep time and sleep efficiency of the observation group at the end of the course were higher than the control group(P<0.05); The sleep latency of the observation group at the end of the course was lower than the control group(P<0.05); The score of psychosocial, motivation and energy, symptoms and adverse reactions for the observation group at the end of the course were lower than the control group(P<0.05); There were no significant difference on the untoward effect rate between the two groups(P>0.05).

Conclusion   It has prominent clinical effects in patients with schizophrenia by olanzapine with amisulpride. It can improve the sleep quality, cognitive function and living quality. It worth of clinical recommendations.

Key words: Schizophrenia; Olanzapine; Amisulpride; Sleep quality, Cognitive function

引用本文 / How to Cite This Article

张志勇.奥氮平联合氨磺必利治疗精神分裂症的效果及对睡眠和认知功能的影响[J]. 国际精神病学杂志, 2020, 47(1): 43-45

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