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住院未成年精神疾病患者抗精神病药物使用情况调查

  • 易文英,吴海波,佘生林,张杰

* 通信作者: 张杰, 单位:广州医科大学附属脑科医院 510011

摘要

摘要
目的:调查2018年广州医科大学附属脑科医院住院未成年精神疾病患者抗精神病药物使用情况,

方法:通过电子住院信息系统收集2018年广州医科大学附属脑科医院所有住院年龄≤ 18岁且确诊为精神疾病的患者的临床、人口学和出院当日使用抗精神病药物情况,进行统计和分析。

结果:共入组626例未成年精神疾病患者,出院时93例(14.9%)患者未使用抗精神病药物,92例(16.7%)患者接受两种抗精神病药物联合治疗,441例(70.4%)患者使用一种抗精神病药物治疗;双相障碍(233例)、抑郁症(124例)、精神分裂症(108例)是诊断频率最高的三种精神疾病,其抗精神病药物使用率为别为94.0%、74.2%和99.1%。使用频率最高五种抗精神病药物依次为喹硫平、奥氮平、阿立哌唑、利培酮和帕利哌酮;双相障碍和抑郁症使用频率最高的抗精神病药物为喹硫平,精神分裂症最常使用奥氮平;儿童组患者最常使用阿立哌唑,青少年组患者最常使用喹硫平;男性患者最常使用奥氮平,女性患者最常使用喹硫平。儿童组患者阿立哌唑、利培酮和喹硫平剂量显著低于青少年组,男女两组间抗精神病药物剂量无显著差异。

结论:绝大部分住院未成年精神疾病患者在出院时接受单种抗精神病药物治疗,不同诊断抗精神病药物使用种类不同,不同年龄组抗精神病药物使用种类、剂量不同。 关键词:儿童;青少年;未成年;精神疾病;抗精神病药物

关键词:儿童;青少年;未成年;精神疾病;抗精神病药物

ABSTRACT

Abstract
Objective: to investigate the use of antipsychotics in child and adolescent inpatients with mental disorders in the Affiliated Brain Hospital of Guangzhou Medical University in 2018.

Methods: we screened the hospital electric data of all the patients ≤ 18 years with a diagnosis of mental disorders who admitted Affiliated Brain Hospital of Guangzhou Medical University from January 1 to December 31, 2018. Clinical and demographical information and the pharmacological treatment of these patients at the day discharge from the hospital were recorded and assessed.

Results: at last this study included 626 child and adolescent inpatients with mental disorders. At discharge, 93 patients (14.9%) were not prescribed antipsychotics, 92 patients (16.7%) were prescribed two antipsychotics, 441 patients (70.4%) were prescribed one antipsychotic. Bipolar disorder (n=233), depression (n=124) and schizophrenia (n=108) were the most frequently diagnosis, and the prevalence of antipsychotics use in that three diagnosis was 94.0%、74.2% and 99.1%, respectively. The most frequently used antipsychotics in the present study was quetiapine, olanzapine, aripiprazole, risperidone and paliperidone. The most frequently used antipsychotic in bipolar disorder, depression and schizophrenia were quetiapine, quetiapine and olanzapine, respectively. The most frequently used antipsychotics in child patients and adolescent patients was aripiprazole and quetiapine, respectively. he most frequently used antipsychotics in male patients and female patients was olanzapine and quetiapine, repectively. The mean daily dosage of antipsychotic in child patients was significantly higher than that in adolescent patients. There were no significantly gender difference in mean daily dosage of antipsychotic.

Conclusion  : Most of child and adolescent patients were prescribed antipsychotic monotherapy. There were difference in antipsychotics use in child and adolescent patients with different diagnosis. There were difference in the kind and mean daily dosage of antipsychotics between child patients and adolescent patients. Keywords: Child, adolescent, mental disorders, antipsychotics

Key words: Keywords: Child;adolescent;mental disorders;antipsychotics

引用本文 / How to Cite This Article

易文英,吴海波,佘生林,张杰.住院未成年精神疾病患者抗精神病药物使用情况调查[J]. 国际精神病学杂志, 2021, 48(4): 615-619

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