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阿立哌唑联合喹硫平治疗女性精神分裂症对性激素及糖脂代谢的影响

  • 侯莹莹

* 通信作者: 侯莹莹, 单位:漯河市中心医院精神科

摘要

【摘要】
目的 探讨阿立哌唑联合喹硫平治疗女性精神分裂症疗效及对性激素及糖脂代谢的影响。

方法 本研究对象为2019年1月~2020年8月70例女性精神分裂症患者,数字表法随机均分为两组,对照组采用喹硫平治疗,观察组在对照组基础上联合阿立哌唑治疗。比较两组治疗前后阳性与阴性症状量表(PANSS)、性激素以及糖脂代谢指标。

结果 治疗后两组PANSS量表中阳性症状、阴性症状、精神症状均显著降低,治疗后观察组显著低于对照组,(P<0.05);治疗后对照组血清雌二醇(E2)水平显著降低、催乳素(PRL)水平显著升高,总胆固醇(TC)、低密度脂蛋白(LDL-C)、空腹血糖均显著升高,(P<0.05),但治疗后观察组与对照组各项指标差异显著,(P<0.05)。

结论 阿立哌唑联合喹硫平治疗女性精神分裂症相较于单用喹硫平能够提升临床疗效,且能降低对糖脂代谢、性激素的影响。

关键词:关键词:阿立哌唑;喹硫平;女性精神分裂症;性激素;糖脂代谢

ABSTRACT

[Abstract]
Objective To explore the efficacy of aripiprazole combined with quetiapine in the treatment of female schizophrenia and its effect on sex hormones and glucose and lipid metabolism.

Methods Seventy female patients with schizophrenia from January 2019 to August 2020 were selected, and they were randomly divided into two groups using the number table method. The control group was treated with quetiapine, and the observation group was treated with aripiprazole on the basis of the control group. The Positive and Negative Symptom Scale (PANSS), sex hormones, and glucose and lipid metabolism indexes between the two groups before and after treatment were compared.

Results After treatment, the positive symptoms, negative symptoms, and total scores in the PANSS scale of the two groups were significantly reduced, and the observation group was significantly lower than the control group after treatment (P<0.05). After treatment, the serum estradiol (E2) level of the control group was significantly reduced, the prolactin (PRL) level was significantly increased, and the serum total cholesterol (TC), low-density lipoprotein (LDL-C), and fasting blood glucose were significantly increased (P<0.05). But after treatment, the observation group and the control group had significant differences in various indicators (P<0.05).

Conclusion   Compared with quetiapine alone in the treatment of female schizophrenia, aripiprazole combined with quetiapine can improve the clinical efficacy, and can reduce the effect on glucose and lipid metabolism and sex hormones.

Key words: Key words Aripiprazole; Quetiapine; Female Schizophrenia; Sex Hormones; Glucose and Lipid Metabolism

引用本文 / How to Cite This Article

侯莹莹.阿立哌唑联合喹硫平治疗女性精神分裂症对性激素及糖脂代谢的影响[J]. 国际精神病学杂志, 2021, 48(4): 637-639

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