本刊首页 > 期刊目次 > 双歧三联活菌联合四联疗法对Hp阳性CAG伴焦虑抑郁患者心理状态、炎性因子水平及肠道菌群的影响

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双歧三联活菌联合四联疗法对Hp阳性CAG伴焦虑抑郁患者心理状态、炎性因子水平及肠道菌群的影响

  • 王自启

* 通信作者: 王自启, 单位:鹤壁市人民医院消化血液内科

摘要

【摘要】
目的:探究双歧三联活菌联合四联疗法对幽门螺杆菌(Hp)阳性慢性萎缩性胃炎(CAG)伴焦虑抑郁患者心理状态、炎性因子水平及肠道菌群的影响。

方法:选取我科2018年8月至2020年12月期间107例Hp阳性CAG伴焦虑抑郁患者,采用信封法将其分为两组,对照组53例给予四联疗法Hp根除治疗,观察组54例联合双歧三联活菌进行治疗,对比两组患者临床疗效、Hp根除率,不良心理状态、炎性因子水平、肠道菌群。

结果:治疗后观察组的临床疗效、Hp根除率、乳酸菌属、双歧杆菌属数量高于对照组,汉密尔顿焦虑量表、汉密尔顿抑郁量表评分、白细胞介素6、C反应蛋白及肿瘤坏死因子α、大肠埃希菌、梭菌属、拟杆菌属水平低于对照组,(P<0.05)。

结论:双歧三联活菌联合四联疗法可以明显提高Hp阳性CAG伴焦虑抑郁患者治疗效果和Hp根除率,降低炎性因子水平,改善肠道菌群数量,缓解患者焦虑抑郁状态。

关键词:【关键词】双歧三联活菌;幽门螺杆菌;慢性萎缩性胃炎;焦虑抑郁

ABSTRACT

[Abstract]
Objective: To explore the effects of bifidobacterium triad live combined with quadruple therapy on psychological state, inflammatory factor level and intestinal microflora of Helicobacter pylori (Hp) positive chronic atrophic gastritis (CAG) patients with anxiety and depression.

Methods:A total of 107 Hp-positive CAG patients with anxiety and depression in our department from August 2018 to December 2020 were selected, and they were divided into two groups using the envelope method. The control group received 53 patients with quadruple therapy Hp eradication treatment, and the observation group 54 patients combined Bifidus triple viable bacteria were treated, and the clinical efficacy, Hp eradication rate, adverse mental state, inflammatory factor levels, and intestinal flora were compared between the two groups of patients.

Results: After treatment, the clinical efficacy, Hp eradication rate, number of Lactobacillus and Bifidobacterium in the observation group were higher than those in the control group, Hamilton Anxiety Scale , Hamilton Depression Scale score, interleukin 6 The levels of C-reactive protein and tumor necrosis factor alpha , Escherichia coli, Clostridium, and Bacteroides were lower than those of the control group (P<0.05).

Conclusion  :Bifidus triple viable bacteria combined with quadruple therapy can significantly improve the treatment effect and eradication rate of Hp-positive CAG patients with anxiety and depression, reduce the level of inflammatory factors, improve the number of intestinal flora, and relieve the anxiety and depression of patients。

Key words: 【Keywords】 Bifidobacterium triad; Helicobacter pylori; Chronic atrophic gastritis; Anxiety and depression

引用本文 / How to Cite This Article

王自启.双歧三联活菌联合四联疗法对Hp阳性CAG伴焦虑抑郁患者心理状态、炎性因子水平及肠道菌群的影响[J]. 国际精神病学杂志, 2021, 48(4): 715-717

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