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短链脂肪酸在精神疾病中的研究进展

  • 彭会清,陈晓岗

* 通信作者: 陈晓岗, 单位:中南大学湘雅二医院精神卫生研究所 410011

摘要

精神系统疾病的发病机制研究已不再局限于脑内,微生物-肠-脑轴的提出对 肠道与中枢神经系统的交互方式有了进一步深入了解。短链脂肪酸作为肠道微生 物的主要代谢产物,本身具有透过血脑屏障的特点,并能通过代谢、免疫、神经 内分泌、迷走神经等多方面影响中枢神经系统,在精神系统疾病中的影响和治疗 潜力值得研究和期待。

关键词:短链脂肪酸;精神疾病;肠-脑轴

ABSTRACT

The research on the pathogenesis of psychiatric diseases is no longer confined to the brain. The proposed microbial-enteric-brain axis provides a further understanding of the interaction between the intestinal tract and the central nervous system. As the main metabolites of intestinal microorganisms, short-chain fatty acids themselves have the characteristics of passing through the blood-brain barrier, and can affect the central nervous system through many aspects such as metabolism, immunity, neuroendocrine, and vagus nerve. Therefore, the effects and therapeutic potential of short-chain fatty acids in psychiatric diseases are worth studying and looking forward to.

Key words: short-chain fatty acid ;Mental illness;Shaft bowel and the brain

引用本文 / How to Cite This Article

彭会清,陈晓岗.短链脂肪酸在精神疾病中的研究进展[J]. 国际精神病学杂志, 2021, 48(4): 577-579

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