摘要

【摘要】
目的 分析帕金森病合并焦虑抑郁状态患者应用文拉法辛辅助治疗后疗效及对患者不良心理状态、认知功能的影响。

方法 选取本院收治的帕金森病合并焦虑抑郁状态患者119例，应用随机数字表法进行分组，对照组患者59例，给予常规药物联合心理干预进行治疗，观察组60例患者增加文拉法辛缓释胶囊辅助治疗，对比两组患者临床疗效、认知功能、症状、心理状态及不良反应。

结果 观察组患者总有效率高于对照组，事件相关电位P300潜伏期低于对照组，蒙特利尔认知评估量表（MoCA）评分、事件相关电位P300波幅、简易智力状态检查量表（MMSE）评分高于对照组，汉密顿抑郁量表（HAMD）评分、帕金森病综合评分量表（UPDRS）评分、汉密尔顿焦虑量表（HAMA）评分低于对照组（P<0.05）；两组患者不良反应发生率无统计学意义（P>0.05）。

结论 文拉法辛辅助治疗帕金森病合并焦虑抑郁状态患者效果显著，有效缓解患者焦虑抑郁状态，控制患者症状，改善患者认知功能，安全性较高。

关键词：【关键词】文拉法辛；帕金森；焦虑；抑郁；认知功能

ABSTRACT

[Abstract]
Objective To analyze the effects of venlafaxine adjuvant therapy on patients with Parkinson's disease combined with anxiety and depression, and its influence on the patients' poor mental state and cognitive function.

Methods A total of 119 patients with Parkinson's disease combined with anxiety and depression in our hospital were selected and grouped by random number table. 59 patients in the control group were treated with conventional drugs and psychological intervention. 60 patients in the observation group were treated with venlafaxine. Sustained-release capsule adjuvant therapy, the clinical efficacy, cognitive function, symptoms, psychological status and adverse reactions of the two groups of patients were compared.

Results The total effective rate of the observation group was higher than that of the control group, the event-related potential P300 latency was lower than that of the control group, the Montreal Cognitive Assessment Scale (MoCA) score, event-related potential P300 amplitude, and the Mini Mental State Examination Scale (MMSE) score were higher. In the control group, the scores of Hamilton Depression Scale (HAMD), Parkinson's Disease Comprehensive Rating Scale (UPDRS) and Hamilton Anxiety Scale (HAMA) were lower than those of the control group (P<0.05); adverse reactions of the two groups of patients The incidence was not statistically significant (P>0.05).

Conclusion   Venlafaxine has a significant effect in adjuvant treatment of patients with Parkinson's disease combined with anxiety and depression. It can effectively relieve the anxiety and depression of the patients, control the symptoms of the patients, and improve the cognitive function of the patients. The safety is high.

Key words: [Keywords] venlafaxine; Parkinson; anxiety; depression; cognitive function