摘要

【摘要】
目的 探讨肺癌化疗患者抑郁状态影响因素及合并抑郁对免疫功能的影响。

方法 本研究对象为2019年1月~2023年4月80例肺癌化疗患者，采用汉密尔顿抑郁量表(hamilton depression scale, HAMD)进行抑郁评估，设为抑郁组与非抑郁组。收集患者年龄、性别等一般资料，logistic回归分析调查抑郁的影响因素。比较抑郁组与非抑郁组T淋巴细胞水平。

结果 80例肺癌化疗患者合并抑郁32例，检出率40.00%；抑郁组与非抑郁组年龄、文化程度、家庭月收入、TNM分期、不良反应分级差异具有统计学意义（P<0.05）；两组性别、居住地差异无统计学意义（P>0.05）；logistic回归分析显示，小学文化程度、家庭月收入＜3000元、TNM分期Ⅲ~Ⅳ期、Ⅳ级不良反应是肺癌化疗患者抑郁影响因素。抑郁组分化决定族抗原3＋(Differentiation determinant antigen，CD3＋)、CD4＋、CD4＋/CD8＋显著低于非抑郁组，CD8＋显著高于非抑郁组，（P<0.05）。

结论 肺癌化疗患者抑郁检出率较高，文化程度、家庭月收入低等可能增加抑郁风险，且合并抑郁会降低患者免疫功能。

关键词：关键词：肺癌;化疗;抑郁状态;免疫功能

ABSTRACT

[Abstract]
Objective To explore the influencing factors of depression in lung cancer chemotherapy patients and the impact of combined depression on immune function.

Methods Eighty lung cancer chemotherapy patients from January 2019 to April February 2023 were selected as the study subjects. The Hamilton Depression Scale (HAMD) was used for depression assessment, and divided into the depression group and the non depression group. The general information such as patient age and gender were collected. Logistic regression analysis were used to investigate the influencing factors of depression. The T lymphocyte levels between the depressive and non depressive groups were compared.

Results Among 80 lung cancer chemotherapy patients, 32 were complicated with depression, with a detection rate of 40.00%; There were statistically significant differences in age, education level, monthly family income, TNM staging, and adverse reaction grading between the depression group and the non depression group (P<0.05). There was no statistically significant difference in gender and place of residence between the two groups (P>0.05). Logistic regression analysis showed that primary school education level, family monthly income<3000 yuan, TNM stage III-IV, and grade IV adverse reactions were the influencing factors for depression in lung cancer chemotherapy patients.The differentiation determining antigen 3+(CD3+), CD4+, CD4+/CD8+in the depression group were significantly lower than those in the non depression group, and CD8+was significantly higher than those in the non depression group (P<0.05).

Conclusion   The detection rate of depression in lung cancer chemotherapy patients is relatively high, and low educational level and monthly family income may increase the risk of depression. Moreover, combined depression can reduce the patient's immune function.

Key words: Key words Lung Cancer; Chemotherapy; Depression State; Immunologic Function