国际精神病学杂志--大牛智慧平台

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双相情感障碍患者糖脂变化的性别差异及其相关性

苏婵,李荷花,李含秋,郭伟坚,黄园园

* 通信作者：李含秋 单位：广州医科大学附属脑科医院

摘要

【摘要】
目的探索双相情感障碍(bipolar disorder, BD)患者临床资料与治疗前后糖脂变化的性别差异及其相关性。

方法回顾性收集BD患者的临床资料和糖脂类指标，其中男女各78、37例。

结果治疗前两组患者住院天数、精神病性症状、甘油三酯、高密度脂蛋白胆固醇(HDL)和抗抑郁药使用上的差异有统计学意义（P<0.05）；两组在治疗前后HDL差值的组间差异有统计学意义(P<0.05)；男性中治疗前后葡萄糖差值与情绪稳定剂使用（r=-0.40,P<0.01）呈负相关，糖化血清蛋白(GSP)差值与年龄（r=0.23,P=0.04）、病程（r=0.24,P=0.04）呈正相关。女性中治疗前后GSP差值与受教育年限（r=-0.40,P=0.01）呈负相关，糖化血红蛋白差值与抗抑郁药使用（r=-0.44,P<0.01）呈负相关，总胆固醇差值与受教育年限（r=0.36,P=0.03）呈正相关。

结论 BD患者治疗前后的糖脂变化及相关因素存在性别差异。

关键词：双相情感障碍；性别；血糖；血脂；相关性

ABSTRACT

【Abstract】
Objective To investigate the gender differences and correlation between clinical data and changes in glucose and lipid levels before and after treatment in patients with bipolar disorder(BD).

Methods Collect 78 and 37 male and 37 female BD patients, and analyze their clinical data and glucose lipid indicators.

Results There were statistically significant differences in hospitalization days, psychiatric symptoms, triglyceride, High-density lipoprotein cholesterol(HDL), and antidepressant use between the two groups before treatment (P<0.05); Before and after treatment, there was a statistically significant difference in the levels of HDL between the two groups (P<0.05); Spearman correlation analysis by gender grouping showed a negative correlation between the increasing of glucose and mood stabilizer use (r=-0.40, P<0.01) in males, while the change of Glycosylated serum protein(GSP) was positively correlated with age (r=0.23, P=0.04) and course of disease (r=0.24, P=0.04). Among women, the change of GSP was negatively correlated with years of education (r=-0.40, P=0.01), the difference of glycosylated hemoglobin was negatively correlated with antidepressant use (r=-0.44, P<0.01), and the increasing of TC was positively correlated with years of education (r=0.36, P=0.03).

Conclusion There are gender differences in the changes in glucose and lipid levels and related factors in BD patients before and after treatment.

Key words: bipolar disorder; gender; blood sugar;blood fat; correlation

引用本文 / How to Cite This Article

苏婵,李荷花,李含秋,郭伟坚,黄园园.双相情感障碍患者糖脂变化的性别差异及其相关性[J]. 国际精神病学杂志, 2025, 52(2): 431-433

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