摘要

[摘要]
目的：探究原发性高血压患者抑郁焦虑状态对其血压控制、血清同型半胱氨酸（Homocysteine，Hcy）水平和生活质量的影响。

方法：择2021年5月-2023年5月间就诊于我院的115例原发性高血压患者，依据其是否合并抑郁、焦虑状态进行分组，比较两组基础资料、血清Hcy水平、血压控制情况和生活质量评分，以pearson检验分析原发性高血压患者血压控制、血清Hcy水平和生活质量与抑郁、焦虑状态间的相关性，分析抑郁、焦虑情绪对其血清Hcy水平、生活质量和血压控制情况的影响。

结果：115例患者中，伴抑郁或（和）焦虑状态者42例，为合并组，无抑郁、焦虑状态者73例，为单纯组。两组文化水平、性别、喝酒史、病程、吸烟史无统计学差异（P＞0.05），单纯组血压控制情况好于合并组，GAD-7焦虑量评分、血清Hcy和PHQ-9抑郁量表评分低于合并组，社会功能、精神健康、情感职能、活力、躯体疼痛、总体健康、生理功能和生理职能评分高于合并组，行pearson检验得，原发性高血压患者GAD-7评分、PHQ-9评分与其血清Hcy和血压控制情况呈正相关，与社会功能、精神健康、情感职能、活力、躯体疼痛、总体健康、生理功能和生理职能评分呈负相关，差异有统计学意义（P＜0.05）。

结论：抑郁焦虑状态可引起原发性高血压患者血清Hcy升高，并降低其血压控制情况和生活质量。

关键词：[关键词]：抑郁焦虑状态；原发性高血压；血清Hcy；生活质量；血压控制

ABSTRACT

[Abstract]
Objective: To explore the effects of depression and anxiety on blood pressure control, serum Hcy level and quality of life in patients with essential hypertension. Method: 115 patients with essential hypertension admitted to our hospital from May 2021 to May 2023 were divided into groups according to whether they were combined with depression and anxiety. The basic data, serum Hcy level, blood pressure control and quality of life score of the two groups were compared. pearson test was used to analyze the correlation between blood pressure control, serum Hcy level, quality of life and depression and anxiety in patients with essential hypertension, and to analyze the effects of depression and anxiety on serum Hcy level, quality of life and blood pressure control.

Results: Among the 115 patients, 42 patients with depression or (and) anxiety were in the combined group, and 73 patients without depression or anxiety were in the simple group. There were no significant differences in literacy level, gender, drinking history, course of disease and smoking history between the two groups (P > 0.05). The simple group had better blood pressure control than the combined group, and the scores of GAD-7, serum Hcy and PHQ-9 were lower than those of the combined group. Social function, mental health, emotional function, vitality, physical pain, general health, physiological function and physiological function scores were higher than those in the combined group. pearson test showed that GAD-7 score and PHQ-9 score of patients with essential hypertension were positively correlated with their serum Hcy and blood pressure control. It was negatively correlated with social function, mental health, emotional function, vitality, physical pain, general health, physiological function and physiological function score, and the difference was statistically significant (P < 0.05).

Conclusion  : Depression and anxiety can increase serum Hcy and decrease blood pressure control and quality of life in patients with essential hypertension.

Key words: [Key words]: depression and anxiety; Essential hypertension; Serum Hcy; Quality of life; Blood pressure control