摘要

【摘要】
目的：探索联合不同剂量阿立哌唑对长期住院的男性精神分裂症患者的远期疗效以及催乳素代谢的影响。

方法：采取前瞻性、随机、对照的研究设计，将在治疗过程中出现高泌乳素血症者随机分配到甲组联合5mg阿立哌唑，乙组联合≧10mg的阿立哌唑，丙组为观察组（不做特殊处理），比较治疗前、治疗后4W、8W、12W泌乳素水平，阳性与阴性症状量表（PANSS）评估疗效，副反应量表（TESS）评定治疗期间的不良反应。

结果：三组年龄、病程、使用药物剂量、基线泌乳素比较均无统计学意义（P＞0.05）；治疗4W后，甲乙两干预组泌乳素下降明显，组间比较差异显著（F=28.200，P＜0.01），乙组在治疗4W后与甲组比较有统计学意义，（P＜0.05）；在治疗8W、12W后比较差异仍显著，（P＜0.01）；甲乙组治疗前后比较有差异，治疗在4W就有明显效果，甲组4W后到12W无差异性；丙组12周后各时点与基线比较无差异（P>0.05）；三组治疗后组间阴性分值比较有统计学意义（P＜0.05））；丙组不良反应发生率高于甲乙组，差异有统计学意义(P＜0.01）。

结论：联合阿立哌唑治疗后可以显著降低催乳素水平，有剂量效应关系，同时改善了临床症状，未增加不良反应发生。

关键词：男性 精神分裂症 阿立哌唑 催乳素

ABSTRACT

[Abstract]
Objective: To explore the long-term efficacy of combining different doses of aripiprazole in male patients with schizophrenia who have been hospitalized for a long time, as well as the influence on prolactin metabolism.Method:A prospective, randomized, controlled study was conducted. Patients with hyperprolactinemia during treatment were randomly assigned to Group A, receiving 5mg of aripiprazole in combination, Group B, receiving ≥10mg of aripiprazole in combination, and Group C, an observation group (no special treatment). Prolactin levels were compared before treatment, and at 4, 8, and 12 weeks after treatment. Efficacy was assessed using the Positive and Negative Syndrome Scale (PANSS), and adverse reactions during treatment were evaluated using the Treatment Emergent Symptom Scale (TESS)

Results:difference compared to Group A after 4 weeks of treatment (P < 0.05). The differences remained significant at 8 and 12 weeks of treatment (P < 0.01). There were differences between Groups A and B before and after treatment, with significant effects observed at 4 weeks; however, there was no difference in Group A from 4 to 12 weeks. There were no significant differences between Group C at various time points after 12 weeks compared to baseline (P > 0.05). There was a statistically significant difference in negative score comparisons among the three groups after treatment (P < 0.05). The incidence of adverse reactions in Group C was higher than that in Groups A and B, with a statistically significant difference (P < 0.01).

Conclusion  : Combination therapy with aripiprazole can significantly reduce prolactin levels, with a dose-effect relationship, while improving clinical symptoms without increasing the incidence of adverse reactions.

Key words: Male; schizophrenia; aripiprazole ;prolactin