摘要

［摘要］ 背景：氯氮平是第二代非典型抗精神病药物,对治疗精神分裂症患者有着极好的疗效,尤其是难治性精神分裂症,但使用氯氮平治疗的部分精神分裂症患者可能会导致心肌炎、心肌病、心律失常等心脏毒性。目前对于氯氮平相关性心肌炎的发病机制、诊断依据、氯氮平相关性心肌炎的再激发、及其治疗尚无明确定论。
目的：本文总结氯氮平所致精神分裂症患者心肌炎的相关进展,以此来更好的指导氯氮平的使用。

结论：氯氮平相关性心肌炎目前尚无明确的诊断及治疗标准,但当精神分裂症患者发生氯氮平相关性心肌炎在小心、谨慎的监督下仍可再次使用,目前电休克治疗联合药物治疗氯氮平相关性心肌炎可能是一个不错的

方法。

关键词：氯氮平;氯氮平相关性心肌炎

ABSTRACT

[Abstract] Background: Clozapine, a second-generation atypical antipsychotic, has excellent efficacy in the treatment of schizophrenia, especially refractory schizophrenia, but the use of clozapine in some schizophrenia patients may lead to cardiotoxicity such as myocarditis, cardiomyopathy, and arrhythmia. At present, there is no clear conclusion on the pathogenesis, diagnostic basis, re-initiation of clozapine-associated myocarditis, and its treatment. OBJECTIVE: This article summarises the progress of clozapine-induced myocarditis in patients with schizophrenia, in order to better guide the use of clozapine. CONCLUSION: There is no clear diagnostic and therapeutic standard for clozapine-associated myocarditis, but clozapine-associated myocarditis can be reintroduced in schizophrenic patients under careful and prudent supervision, and electroconvulsive therapy (ECT) combined with pharmacological treatment of clozapine-associated myocarditis may be a good method. Translated with DeepL.com (free version)

Key words: Clozapine;Clozapine-associated myocarditis