摘要

目的：工作记忆缺陷是精神分裂症认知受损的核心，而刷新功能是工作记忆的核心，是否随着病程的延长而加重的问题仍然存在争议。本研究以不同病程的精神分裂症患者为研究对象，探讨病程、症状与刷新功能的相关性。

方法：选取 233名不同病程的精神分裂患者作为研究对象，采用PANSS量表评估精神症状的严重程度，分别使用刷新1750任务、750任务和2-back任务测量患者的在工作记忆方面的不同刷新能力。

结果：病程、阴性症状与精神分裂患者的刷新能力(1750任务、750任务和2-back任务)呈负相关。

结论：精神分裂症患者的工作记忆刷新能力随着病程的延长逐渐下降，亦随着阴性症状的加重而加重。

关键词：病程；精神分裂症；工作记忆；刷新

ABSTRACT

Objective: Impaired working memory is the heart of cognitive deficits in schizophrenia, and the ability to updating is the heart of working memory. The question of whether working memory impairment declines with the course of the disease remains controversial. This study took schizophrenia patients with different courses as the research objects to explore the correlation between course, symptoms and updating function.

Methods: 233 schizophrenia patients with different course of disease were selected as the research objects. The PANSS scale was used to evaluate the severity of mental symptoms, and the 1750 task, the 750 task and the 2-back task were used to measure the working memory updating ability of the patients.

Results: The results of the study found that the course, negative symptoms were negatively correlated with updating ability memory updating ability of individuals with schizophrenia gradually diminishes as the illness progresses, and it deteriorates further with the escalation of negative symptoms.

Key words: Course of the disease; Schizophrenia; Working memory; Updating