摘要

微生物-肠-脑（Microbiota-Gut-Brain, MGB）轴在双相障碍（Bipolar disorders, BD）病理生理机制中具有重要作用，并且通过靶向干预可能改善患者预后。本文将从肠道微生物对双相障碍的影响、MGB轴在双相障碍治疗中的潜在机制或靶点以及MGB轴在双相障碍治疗中的作用进行综述。

关键词：双相障碍；微生物-肠-脑轴；肠道微生物；肠道通透性；菌群移植

ABSTRACT

The Microbiota-Gut-Brain (MGB) axis plays a pivotal role in the pathophysiological mechanisms of Bipolar Disorders (BD), and targeted interventions along this axis may potentially improve patient outcomes. This paper aims to provide a comprehensive review on the impact of gut microbiota on BD, the potential mechanisms or targets of the MGB axis in BD treatment, as well as the role of the MGB axis in therapeutic strategies for BD.

Key words: Bipolar disorders；Microbiota–Gut–Brain Axis；Gut microbiota；intestinal permeability；Fecal Microbiota Transplantation