摘要

【摘要】
目的 探讨精神分裂症患者外周血白细胞、中性粒细胞、淋巴细胞、中性粒细胞-淋巴细胞比值、CRP、IL-6和铜蓝蛋白水平的变化及其意义，为相关精神疾病的发病机制与临床诊疗研究提供理论参考依据。

方法 纳入2024年1月至2024年6月期间佛山市第三人民医院接收的74例精神分裂症患者以及50例健康体检者作为对照，精神分裂症患者给予常规治疗，检测治疗前及治疗4周后及对照组入院时外周血白细胞、中性粒细胞、淋巴细胞、中性粒细胞-淋巴细胞比值、CRP、IL-6和铜蓝蛋白水平；比较外周血白细胞、中性粒细胞、淋巴细胞、中性粒细胞-淋巴细胞比值、CRP、IL-6和铜蓝蛋白水平在精神分裂症患者治疗前及治疗4周后的变化趋势。

结果 精神分裂症患者组在治疗前，其外周血白细胞绝对值、中性粒细胞绝对值、中性粒细胞-淋巴细胞比值、CRP、IL-6、铜蓝蛋白均明显高于健康对照，差异有统计学意义（所有P<0.05）；外周血淋巴细胞绝对值则明显低于健康对照，差异有统计学意义（P<0.05）；治疗4周后，其外周血白细胞绝对值、中性粒细胞绝对值、中性粒细胞-淋巴细胞比值、铜蓝蛋白均明显低于治疗前，差异有统计学意义（所有P<0.05）；外周血淋巴细胞绝对值则明显高于健康对照，差异有统计学意义（P<0.05）。

结论 外周血中性粒细胞-淋巴细胞比值、CRP、IL-6和铜蓝蛋白水平与精神分裂症病情相关，可为精神分裂症的临床诊断、治疗指导及预后评估提供参考。

关键词：精神分裂症；粒淋比；CRP；IL-6；铜蓝蛋白

ABSTRACT

[Abstract]
Objective To explore the changes and significance of peripheral blood leukocytes, neutrophils, lymphocytes, neutrophil-lymphocyte ratio, CRP, IL-6, and ceruloplasmin levels in patients with schizophrenia, in order to provide a theoretical reference for the pathogenesis, diagnosis and treatment of related mental diseases.

Methods The study included 74 patients with schizophrenia and 50 healthy controls received at the Third People's Hospital of Foshan City from January to June 2024. Patients with schizophrenia were given standard treatment. Levels of peripheral blood white blood cells, neutrophils, lymphocytes, neutrophil-to-lymphocyte ratio, CRP, IL-6, and ceruloplasmin were measured before treatment and after four weeks of treatment, as well as at admission for the control group. The trends in changes in these levels before and after treatment in patients with schizophrenia were compared.

Results Before treatment, the absolute values of peripheral blood white blood cells, neutrophils, neutrophil-to-lymphocyte ratio, CRP, IL-6, and ceruloplasmin in the schizophrenia group were significantly higher than those in the healthy control group (all P<0.05); while the absolute values of lymphocytes were significantly lower than those in the healthy control group (P<0.05). After four weeks of treatment, the absolute values of peripheral blood white blood cells, neutrophils, neutrophil-to-lymphocyte ratio, and ceruloplasmin were significantly lower than before treatment (all P<0.05); while the absolute values of lymphocytes were significantly higher than in the healthy control group (P<0.05).

Conclusion   The levels of neutrophil-to-lymphocyte ratio, CRP, IL-6, and ceruloplasmin in peripheral blood are related to the severity of schizophrenia and can provide references for clinical diagnosis, treatment guidance, and prognosis assessment of schizophrenia.

Key words: Schizophrenia; Neutrophil-Lymphocyte ratio; CRP; IL-6; ceruloplasmin