摘要

摘 要
目的 了解首发未服药精神分裂症患者中心性肥胖的现状和影响因素以及体重校正腰围指数（Weight adjusted waist index， WWI）对代谢指标的影响。

方法 320例首发精神分裂症患者被纳入本次研究，以腰围判断患者是否有中心性肥胖。采用Logistic回归分析患者中心性肥胖的危险因素。采用偏相关分析WWI与代谢指标之间的关系。

结果 首发未服药精神分裂症患者中心性肥胖发生率为23.13%。年龄和体重是精神分裂症患者中心性肥胖的危险因素。体重校正腰围指数与尿酸、空腹胰岛素、胰岛素抵抗、糖化血红蛋白、总胆固醇（Total cholesterol, TC）、甘油三酯（Triglyceride, TG）、低密度脂蛋白（Low-density lipoprotein cholesterol, LDL-C）、收缩压和舒张压成正相关，与高密度脂蛋白（How-density lipoprotein cholesterol, HDL-C）成负相关。

结论 首发未服药精神分裂症患者中心性肥胖率较高，且WWI与代谢指标密切相关，为预防首发未服药的精神分裂症患者中心性肥胖提供理论支持。

关键词：精神分裂症；体重；腰围；代谢

ABSTRACT

Abstract:
Objective To investigate the prevalence and influenced factors of central obesity in first-episode drug-naive schizophrenia patients as well as the effect of weight-adjusted waist index (WWI) on metabolic indicators.

Methods 320 first-episode drug-naive schizophrenia patients were enrolled into this study and the waist circumference was used to express central obesity. Logistic regression was employed to analyze the risk factors associated with central obesity. Partial correction was utilized to analyze the relationship between WWI and several metabolic indicators.

Results 23.13% patients were found to be central obesity. Age and weight were associated with central obesity of schizophrenia patients. Correction analysis showed WWI was positively related to , whereas WWI was negatively associated with HDLC.

Conclusion   First-episode drug-naive schizophrenia patients have higher prevalence of central obesity. WWI is associated with metabolic indicators. In practice, The theoretical support is provided to prevent central obesity in first-episode drug-naive schizophrenia patients.

Key words: schizophrenia; weight; waist circumference; metabolism