摘要

摘要：
目的 探讨抑郁症患者认知功能与睡眠觉醒参数的相关性。

方法 纳入2022年2月-2024年3月85例抑郁症患者，采用简易精神状态评价量表（Mini-mental state examination，‌MMSE）评估患者认知功能，采用睡眠脑电图仪记录睡眠觉醒参数，比较是否具有认知功能障碍患者的睡眠觉醒参数，Spearman分析认知功能障碍组患者‌MMSE评分与睡眠觉醒参数的相关性。

结果 85例抑郁症患者中27例具有认知障碍，均为轻度认知障碍；认知障碍组MMSE评分、总睡眠时间 (Total sleep time, TST)、睡眠效率(Sleep efficiency, SE)、快速眼动睡眠期(Rapid eye nlovenlent, REM)显著低于无认知障碍组，认知障碍组睡眠潜伏期(Sleep onset latency, SOL)、觉醒次数与时间均高于无认知障碍组，（P<0.05）；Spearman分析显示，认知障碍组MMSE评分与TST、SE、REM正相关，与SOL、觉醒次数与时间负相关，（P<0.05）。

结论 抑郁症患者容易发生认知障碍，合并认知障碍患者睡眠时间更短，觉醒时间与次数更多，且睡眠觉醒参数与认知功能具有显著的相关性。

关键词：关键词：抑郁症; 睡眠觉醒参数;睡眠质量；认知功能；认知障碍

ABSTRACT

Abstract:
Objective To explore the correlation between cognitive function and sleep-wake parameters in patients with depression. Method Eighty-five depressed patients February 2022-March 2024 were included. The patients' cognitive functioning was assessed using the Mini-mental state examination (MMSE) scale. Sleep-wake parameter were recorded using sleep electroencephalograph. Sleep-wake parameter were compared between patients in the cognitive dysfunction group as well as in the group without cognitive dysfunction. Spearman's analysis was done to correlate the MMSE scores with the sleep-wake parameter of the patients in the cognitive dysfunction group. Result Twenty-seven of the 85 depressed patients had cognitive impairment, and all of them had mild cognitive impairment. MMSE score, Total sleep time（TST)、Sleep efficiency (SE)、Rapid eye nlovenlent（REM） were significantly lower in cognitive impairment group than in the group without cognitive impairment, and Sleep onset latency(SOL), number of awakenings and time were higher in cognitive impairment group than in the group without cognitive impairment (P<0.05). Spearman's analysis showed that MMSE scores in the cognitive impairment group were positively correlated with TST, SE, and REM, and negatively correlated with SOL, number of awakenings, and time (P<0.05).

Conclusion   Patients with depression are prone to cognitive impairment, and patients with cognitive impairment have shorter sleep time, more awakening time and times, and sleep-wake parameters are significantly correlated with cognitive function.

Key words: Key words Depression; Sleep-wake Parameter; Sleep Quality; Cognitive Function; Cognitive Impairment