摘要

【摘要】
目的 分析原发性肝癌（primary hepatocellular carcinoma，PHC）患者化疗期间抑郁状态的影响因素。

方法 回顾性分析空军军医大学第一附属医院消化内科在2022年1月到2024年1月就诊的120例PHC化疗患者的临床资料，依据抑郁自评量表（Self-rating depression Scale，SDS）将患者分为抑郁组54例（SDS评分≥53分）和非抑郁组66例（SDS评分＜53分）。比较两组患者相关基线资料及主观整体营养评估量表（patient generated subjective global assessment，PG-SGA）等级、白蛋白（albumin，ALB）、前白蛋白（prealbumin，PAB）、转铁蛋白（transferrin，TRF）水平，通过多因素Logistic回归分析PHC患者化疗期间发生抑郁的危险因素，统计两组患者化疗相关不良事件发生情况。

结果 抑郁组PG-SGA评分等级为营养重度不良患者占比显著高于非抑郁组，ALB、PAB、TRF水平显著低于非抑郁组（P＜0.05）；经多因素Logistic回归分析证实，PG-SGA评分等级为营养重度不良、ALB、PAB、TRF水平降低均是PHC患者化疗期间发生抑郁的危险因素，均有P＜0.05；在化疗相关不良事件方面，抑郁组发生率占比均高于非抑郁组（P＜0.05）。

结论 PHC患者化疗期间更易产生抑郁情绪，PG-SGA评分等级、ALB、PAB、TRF水平均是PHC患者化疗期间发生抑郁的影响因素，且抑郁情绪会增加化疗相关不良事件发生风险。

关键词：【关键词】原发性肝癌；化疗；抑郁；影响因素

ABSTRACT

【Abstract】
Objective To analyze the influencing factors of depression in primary hepatocellular carcinoma (PHC) patients during chemotherapy.

Methods Clinical data of 120 patients with PHC receiving chemotherapy in our hospital from January 2022 to January 2024 were retrospectively analyzed. and according to Self-rating depression Scale (self-rating Depression Scale), The patients were divided into depression group 54 cases (SDS ≥53 points) and non-depression group 66 cases (SDS < 53 points). Relative baseline data, patient generated subjective global assessment (PG-SGA) grade, albumin (ALB), prealbumin (PAB) and transferrin (TRF) were compared between the two groups. Multivariate Logistic regression was used to analyze the risk factors of depression in PHC patients during chemotherapy, and the incidence of chemotherapy-related adverse events in the two groups were statistically analyzed..

Results The proportion of patients with PG-SGA score as severe malnutrition in depression group was significantly higher than that in non-depression group, and the levels of ALB, PAB and TRF were significantly lower than those in non-depression group (P<0.05). Multivariate Logistic regression analysis confirmed that PG-SGA grade of severe malnutrition, ALB, PAB, TRF levels decreased were all risk factors for depression during chemotherapy in PHC patients (P<0.05). In terms of chemotherapy-related adverse events, the incidence of depression group was higher than that of non-depression group (P<0.05).

Conclusion   Patients with PHC are more prone to depression during chemotherapy. PG-SGA score, ALB, PAB and TRF levels are all influencing factors for depression during chemotherapy in patients with PHC, and depression will increase the risk of chemotherapy-related adverse events.

Key words: 【Key words】Primary liver cancer; Chemotherapy; Depression; Influencing factor