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基于近红外成像技术探究竞争对抑郁症工作记忆的影响

  • 包凌博,程宇琪,于嘉乐,刘芳,刘卫青

* 通信作者: 刘芳, 单位:昆明医科大学第一附属医院精神科 650032

摘要

【摘要】
目的:探究竞争情境对抑郁症(Major Depressive Disorder , MDD)患者工作记忆表现和神经机制的影响,对比MDD患者和健康对照(Healthy Control , HC)所受影响的差异。揭示MDD患者在竞争影响下工作记忆的变化。

方法:符合诊断标准的MDD患者42人为研究对象,并选择33名健康成人作为HC组,采用数字比较任务作为工作记忆研究范式,应用功能性近红外成像技术观测额颞叶脑区的激活。

结果:1、在正确率上,组别、竞争情境和工作记忆类型上主效应显著(P<0.001)。在竞争情境-工作记忆维持中、非竞争情境-工作记忆操作中,HC的正确率显著高于MDD患者(P<0.05)。HC在工作记忆操作中,非竞争情境的正确率要显著高于竞争情境(P<0.001)。2、在反应时上,组别、竞争情境和工作记忆类型上主效应显著(P<0.001)。各交互效应不显著。3、在背外侧前额叶、布洛卡区(CH37、CH41)中,仅HC的非竞争情境的脑部激活要显著小于竞争情境(P<0.05)。在布洛卡区(CH37)中非竞争情境下,MDD患者的激活要明显的高于HC(P=0.035)。

结论:MDD患者的工作记忆存在显著缺陷,MDD患者面对竞争情境时,工作记忆表现和脑部激活与HC存在显著差异。

关键词:功能性近红外成像技术;抑郁症;工作记忆;竞争

ABSTRACT

Abstract:
Objective: To explore the impact of competitive situations on the working memory performance and neural mechanisms of patients with Major Depressive Disorder (MDD), and to compare the differences in the effects on MDD patients and healthy controls (HC). To reveal the changes in working memory of MDD patients under competitive influence.

Methods: 42 MDD patients meeting diagnostic criteria and 33 healthy adults as the HC group were selected. The digit comparison task was used as the working memory research paradigm, and functional near-infrared imaging technology was applied to observe the activation of the frontal and temporal lobe brain regions.

Results: 1、 In terms of accuracy, the main effects of group, competitive situation, and working memory type were significant (P < 0.001). In the competitive situation - working memory maintenance and non-competitive situation - working memory operation, the accuracy of HC was significantly higher than that of MDD patients (P < 0.05). In the working memory operation of HC, the accuracy in the non-competitive situation was significantly higher than that in the competitive situation (P < 0.001). 2、In terms of reaction time, the main effects of group, competitive situation, and working memory type were significant (P < 0.001). The interaction effects were not significant. 3、In the dorsolateral prefrontal cortex and Broca's area (CH37, CH41), only the brain activation of HC in the non-competitive situation was significantly lower than that in the competitive situation (P < 0.05). In Broca's area (CH37), the activation of MDD patients in the non-competitive situation was significantly higher than that of HC (P = 0.035).

Conclusion  : MDD patients have significant deficits in working memory. When facing competitive situations, the working memory performance and brain activation of MDD patients are significantly different from those of HC.

Key words: functional near-infrared spectroscopy; Depression; Working memory; Competition

引用本文 / How to Cite This Article

包凌博,程宇琪,于嘉乐,刘芳,刘卫青.基于近红外成像技术探究竞争对抑郁症工作记忆的影响[J]. 国际精神病学杂志, 2025, 52(2): 356-363

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