国际精神病学杂志--大牛智慧平台

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边缘型人格障碍神经影像学研究进展

金毅琼,宁小帅,杨伟亮

* 通信作者：杨伟亮 单位：石河子大学第一附属医院

摘要

边缘型人格障碍是一种常见的精神疾病，主要特征为情绪不稳定，自伤自杀行为。其病因和生物学机制目前仍未明确，大量的影像学研究表明边缘型人格障碍的脑结构和功能存在异常，尤其是前额叶-边缘环路，并且其异常改变和临床症状相关。本文总结归纳了近年来边缘型人格障碍结构和功能磁共振成像研究，为进一步的机制研究提供思路。

关键词：边缘型人格障碍，结构磁共振成像，弥散张量成像，功能磁共振成像

ABSTRACT

Abstract: Borderline personality disorder (BPD) is a common mental disorder characterized by instability emotion, self-harming and suicidal behavior. The biologic mechanisms are unclear. Extensive imaging studies showed that the brain structure and function are abnormal in BPD patients, especially the changes of frontolimbic circuit are associated with the symptoms. This study summarizes the structural and functional MRI studies of borderline personality disorder in recent years, and provides ideas for further mechanism research.

Key words: borderline personality disorder, structural MRI, diffusion tensor image, functional MRI

引用本文 / How to Cite This Article

金毅琼,宁小帅,杨伟亮.边缘型人格障碍神经影像学研究进展[J]. 国际精神病学杂志, 2026, 53(3): 697-699

参考文献

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[29] [8] MONKUL E S, HATCH J P, NICOLETTI M A, et al. Fronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorder [J][J]. Mol Psychiatry, 2007, 12(4): 360-6.

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[31] [11] ROSSI R, PIEVANI M, LORENZI M, et al. Structural brain features of borderline personality and bipolar disorders [J][J]. Psychiatry Res, 2013, 213(2): 83-91.

[32] [12] ROSSI R, LANFREDI M, PIEVANI M, et al. Volumetric and topographic differences in hippocampal subdivisions in borderline personality and bipolar disorders [J][J]. Psychiatry Res, 2012, 203(2-3): 132-8.

[33] [13] LABUDDA K, KREISEL S, BEBLO T, et al. Mesiotemporal volume loss associated with disorder severity: a VBM study in borderline personality disorder [J][J]. PLoS One, 2013, 8(12): e83677-.

[34] [14] ROSSI R, LANFREDI M, PIEVANI M, et al. Abnormalities in cortical gray matter density in borderline personality disorder [J][J]. Eur Psychiatry, 2015, 30(2): 221-7.

[35] [15] JIN X, ZHONG M, YAO S, et al. A Voxel-Based Morphometric MRI Study in Young Adults with Borderline Personality Disorder [J][J]. PLoS One, 2016, 11(1): e0147938-.

[36] [16] ZHOU Q, ZHONG M, YAO S, et al. Hemispheric asymmetry of the frontolimbic cortex in young adults with borderline personality disorder [J][J]. Acta Psychiatr Scand, 2017, 136(6): 637-47.

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[38] [19] RICHTER J, BRUNNER R, PARZER P, et al. Reduced cortical and subcortical volumes in female adolescents with borderline personality disorder [J][J]. Psychiatry Res, 2014, 221(3): 179-86.

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[40] [23] GAN J, YI J, ZHONG M, et al. Abnormal white matter structural connectivity in treatment-naive young adults with borderline personality disorder [J][J]. Acta Psychiatr Scand, 2016, 134(6): 494-503.

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[47] [41] HAAS B W, MILLER J D. Borderline personality traits and brain activity during emotional perspective taking [J][J]. Personal Disord, 2015, 6(4): 315-20.

[48] [42] BEENEY J E, HALLQUIST M N, ELLISON W D, et al. Self-other disturbance in borderline personality disorder: Neural, self-report, and performance-based evidence [J][J]. Personal Disord, 2016, 7(1): 28-39.

[49] [1] LEICHSENRING F, LEIBING E, KRUSE J, et al. Borderline personality disorder [J][J]. Lancet, 2011, 377(9759): 74-84.

[50] [2] 郭慧荣,肖泽萍. 边缘型人格障碍的病因与治疗研究现状[J][J]. 国际精神病学杂志, 2005, (03): 190-192.

[51] [3] DOERING S. Borderline Personality Disorder in Patients With Medical Illness: A Review of Assessment, Prevalence, and Treatment Options [J][J]. Psychosom Med, 2019, 81(7): 584-94.

[52] [7] VAN HEERINGEN C, BIJTTEBIER S, GODFRIN K. Suicidal brains: a review of functional and structural brain studies in association with suicidal behaviour [J][J]. Neurosci Biobehav Rev, 2011, 35(3): 688-98.

[53] [8] MONKUL E S, HATCH J P, NICOLETTI M A, et al. Fronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorder [J][J]. Mol Psychiatry, 2007, 12(4): 360-6.

[54] [9] ARAUJO T B, ARAUJO FILHO G M, SATO J R, et al. Cortical morphology changes in women with borderline personality disorder: a multimodal approach [J][J]. Braz J Psychiatry, 2014, 36(1): 32-8.

[55] [11] ROSSI R, PIEVANI M, LORENZI M, et al. Structural brain features of borderline personality and bipolar disorders [J][J]. Psychiatry Res, 2013, 213(2): 83-91.

[56] [12] ROSSI R, LANFREDI M, PIEVANI M, et al. Volumetric and topographic differences in hippocampal subdivisions in borderline personality and bipolar disorders [J][J]. Psychiatry Res, 2012, 203(2-3): 132-8.

[57] [13] LABUDDA K, KREISEL S, BEBLO T, et al. Mesiotemporal volume loss associated with disorder severity: a VBM study in borderline personality disorder [J][J]. PLoS One, 2013, 8(12): e83677-.

[58] [14] ROSSI R, LANFREDI M, PIEVANI M, et al. Abnormalities in cortical gray matter density in borderline personality disorder [J][J]. Eur Psychiatry, 2015, 30(2): 221-7.

[59] [15] JIN X, ZHONG M, YAO S, et al. A Voxel-Based Morphometric MRI Study in Young Adults with Borderline Personality Disorder [J][J]. PLoS One, 2016, 11(1): e0147938-.

[60] [16] ZHOU Q, ZHONG M, YAO S, et al. Hemispheric asymmetry of the frontolimbic cortex in young adults with borderline personality disorder [J][J]. Acta Psychiatr Scand, 2017, 136(6): 637-47.

[61] [17] DEPPING M S, THOMANN P A, WOLF N D, et al. Common and distinct patterns of abnormal cortical gyrification in major depression and borderline personality disorder [J][J]. Eur Neuropsychopharmacol, 2018, 28(10): 1115-25.

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[63] [21] BRUNNER R, HENZE R, PARZER P, et al. Reduced prefrontal and orbitofrontal gray matter in female adolescents with borderline personality disorder: is it disorder specific? [J][J]. Neuroimage, 2010, 49(1): 114-20.

[64] [23] GAN J, YI J, ZHONG M, et al. Abnormal white matter structural connectivity in treatment-naive young adults with borderline personality disorder [J][J]. Acta Psychiatr Scand, 2016, 134(6): 494-503.

[65] [26] NEW A S, CARPENTER D M, PEREZ-RODRIGUEZ M M, et al. Developmental differences in diffusion tensor imaging parameters in borderline personality disorder [J][J]. J Psychiatr Res, 2013, 47(8): 1101-9.

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[68] [37] SPRENG R N, MAR R A, KIM A S. The common neural basis of autobiographical memory, prospection, navigation, theory of mind, and the default mode: a quantitative meta-analysis [J][J]. J Cogn Neurosci, 2009, 21(3): 489-510.

[69] [38] ZHUO C, JI F, LIN X, et al. Common and distinct brain functional alterations in pharmacotherapy treatment-naive female borderline personality disorder patients with and without auditory verbal hallucinations: a pilot study [J][J]. Eur Arch Psychiatry Clin Neurosci, 2021, 271(6): 1149-57.

[70] [39] HAZLETT E A, ZHANG J, NEW A S, et al. Potentiated amygdala response to repeated emotional pictures in borderline personality disorder [J][J]. Biol Psychiatry, 2012, 72(6): 448-56.

[71] [41] HAAS B W, MILLER J D. Borderline personality traits and brain activity during emotional perspective taking [J][J]. Personal Disord, 2015, 6(4): 315-20.

[72] [42] BEENEY J E, HALLQUIST M N, ELLISON W D, et al. Self-other disturbance in borderline personality disorder: Neural, self-report, and performance-based evidence [J][J]. Personal Disord, 2016, 7(1): 28-39.

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