摘要

【摘要】
目的 分析精神分裂症（Schizophrenia，SZ）患者临床症状与血清神经轴突导向因子-1（Netrin-1）、神经调节蛋白-1（Neuregulin-1，NRG-1）水平的关系。

方法 选取2022年6月至2024年6月期间我院收治的80例SZ患者的病历资料进行回顾性分析，并将其设为观察组。另将同期在本院进行体检的90例健康个体设为对照组。对比分析两组阳性及阴性症状量表（Positive And Negative Syndrome Scale，PANSS）评分、血清Netrin-1、NRG-1水平，比较观察组高分和低分患者血清Netrin-1、NRG-1水平，采用Spearman相关系数法分析PANSS评分与血清Netrin-1、NRG-1水平的关系。

结果 相较于对照组，观察组阳性症状、阴性症状、一般精神病理及总分评分数据更高（P＜0.05）；相较于对照组，观察组血清Netrin-1、NRG-1水平数据更低（P＜0.05）；相较于低分组，高分组血清Netrin-1、NRG-1水平数据更低（P＜0.05）；相关性分析表明，血清Netrin-1、NRG-1水平与PANSS各维度评分及总分均呈负相关（P＜0.05）。

结论 SZ患者血清Netrin-1、NRG-1水平与临床症状存在明显相关性，且血清Netrin-1、NRG-1水平越低，患者临床症状越严重，临床上应引起足够重视。

关键词：【关键词】精神分裂症；临床症状；神经轴突导向因子-1；神经调节蛋白-1

ABSTRACT

【Abstract】
Objective To analyze the relationship between clinical symptoms and serum levels of Netrin-1 and Neuregulin-1 (NRG-1) in patients with Schizophrenia (SZ).

Methods The medical records of 80 patients with SZ admitted to our hospital from June 2022 to June 2024 were retrospectively analyzed and set as the observation group. In addition, 90 healthy individuals who underwent physical examination in our hospital during the same period were set as the control group. The Positive And Negative Syndrome Scale (PANSS) score and serum Netrin-1 and NRG-1 levels of the two groups were compared, and the serum levels of Netrin-1 and NRG-1 were compared between high and low scores in observation group. Spearman correlation coefficient was used to analyze the relationship between PANSS score and serum Netrin-1 and NRG-1 levels.

Results Compared with the control group, the positive symptoms, negative symptoms, general psychopathology and total score of the observation group were higher (P＜0.05). Compared with the control group, the serum Netrin-1 and NRG-1 levels in the observation group were lower (P＜0.05). Serum Netrin-1 and NRG-1 levels in high group were lower than those in low group (P＜0.05). Correlation analysis revealed that serum Netrin-1 and NRG-1 levels were negatively correlated with all dimension scores and the total score of PANSS.(P＜0.05).

Conclusion   Serum Netrin-1 and NRG-1 levels of SZ patients are significantly correlated with clinical symptoms, and the lower the serum Netrin-1 and NRG-1 levels, the more serious the clinical symptoms of patients, which should be paid sufficient attention to clinically.

Key words: 【Key words】Schizophrenia; Clinical symptoms; Netrin-1; Neuregulin-1