摘要

【摘要】
目的 探讨单孔腹腔镜术后患者焦虑的影响因素及其与血清白细胞介素-6（Interleukin-6，IL-6）、肿瘤坏死因子-α（Tumor Necrosis Factor-alpha，TNF-α）水平的关系。

方法 选择2022年1月～2025年1月于本院行单孔腹腔镜术的患者80例为研究对象，依据焦虑自评量表（Self-Rating Anxiety Scale，SAS）评分分为焦虑组（n=30）和无焦虑组（n=50）。比较两组临床资料，并经Logistic多因素分析明确影响单孔腹腔镜术后患者焦虑的危险因素。

结果 焦虑组年龄≤50岁、初中及以下、未婚/离异/丧偶、家庭经济条件≤6000元/月的患者占比及血清IL-6、TNF-α水平均高于无焦虑组，均有统计学差异（P＜0.05）。Logistic多因素分析显示，年龄≤50岁、文化程度为初中及以下、家庭经济条件≤6000元/月、婚姻状况为未婚/离异/丧偶、IL-6升高、TNF-α升高均是影响单孔腹腔镜术后患者焦虑发生的危险因素（P＜0.05）。相关性分析显示：血清IL-6、TNF-α水平与单孔腹腔镜术后患者SAS评分均呈正相关关系（P＜0.05）。

结论 单孔腹腔镜术后患者焦虑的发生受年龄、文化程度、家庭经济条件、婚姻状况、IL-6、TNF-α等因素的影响，并且血清IL-6、TNF-α水平与患者术后焦虑密切相关。

关键词：【关键词】 单孔腹腔镜；焦虑；白细胞介素-6；肿瘤坏死因子-α；影响因素

ABSTRACT

【Abstract】
Objective To investigate the influencing factors of anxiety in patients after single port laparoscopic surgery and its relationship with serum interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF - α) levels.

Methods From January 2022 to January 2025, 80 patients with single port laparoscopic surgery in our hospital were selected as the research objects, and were divided into anxiety group (n=30) and non anxiety group (n=50) according to the self rating Anxiety Scale (SAS) score. The clinical data of the two groups were compared, and the risk factors of anxiety in patients after single port laparoscopic surgery were determined by logistic multivariate analysis.

Results The proportion of patients with age ≤ 50 years old, junior high school and below, unmarried/divorced/widowed, family economic conditions ≤ 6000 yuan/month and the levels of serum IL-6 and TNF - α in the anxiety group were higher than those in the non anxiety group, with statistical differences (P<0.05). Logistic multivariate analysis showed that age ≤ 50 years old, education level of junior high school or below, family economic conditions ≤ 6000 yuan/month, marital status of unmarried/divorced/widowed, elevated IL-6 and TNF - α were risk factors for anxiety in patients after single port laparoscopic surgery (P<0.05). Correlation analysis showed that serum IL-6 and TNF - α levels were positively correlated with SAS scores of patients after single port laparoscopic surgery (P<0.05).

Conclusion   The occurrence of anxiety in patients after single port laparoscopic surgery is affected by age, education level, family economic conditions, marital status, IL-6, TNF - α and other factors, and the levels of serum IL-6, TNF - α are closely related to postoperative anxiety.

Key words: 【Key words】 Single port laparoscopy; Anxiety; Interleukin-6; Tumor Necrosis Factor-alpha; Influencing factors