摘要

【摘要】
目的 分析睡眠障碍与妊娠期糖尿病（Gestational Diabetes Mellitus，GDM）患者产后抑郁（Postpartum Depression，PPD）的关系。

方法 选择2023年1月～2024年5月于本院分娩并产后随访的GDM患者136例，根据产后6周爱丁堡产后抑郁量表（Edinburgh Postpartum Depression Scal，EPDS）评分分为PPD组（n=31）和非PPD组（n=105）。记录孕期及产后3d患者匹兹堡睡眠质量指数量表（Pittsburgh Sleep Quality Index，PSQI）评分，检测患者血清白细胞介素-1β（Interleukin-1β，IL-1β）、肿瘤坏死因子-α（Tumor Necrosis Factor-α，TNF-α）水平。

结果 PPD组孕早期、孕中期、孕晚期及产后3d的PSQI评分均高于非PPD组，均有统计学差异（P＜0.05）。相关性分析显示，GDM患者PSQI评分与EPDS评分均呈正相关关系（P＜0.05）。PPD组血清IL-1β、TNF-α水平均高于非PPD组，均有统计学差异（P＜0.05）。

结论 GDM患者孕期及产后早期的睡眠障碍与PPD的发生有关，且血清IL-1β、TNF-α升高也可增加PPD发生风险。结合睡眠障碍、炎性因子升高与PPD的关联性，提示慢性炎症可能是睡眠障碍影响PPD风险的潜在生物学通路，值得深入研究。

关键词：【关键词】 妊娠期糖尿病；睡眠障碍；产后抑郁；相关性

ABSTRACT

【Abstract】
Objective To analyze the correlation between sleep disordersy and postpartum depression (PPD) risk in patients with gestational diabetes mellitus (GDM).

Methods A total of 136 GDM patients who delivered in our hospital from January 2023 to may 2024 and were followed up after delivery were selected and divided into PPD group (n=31) and non PPD group (n=105) according to the Edinburgh Postpartum Depression Scale (EPDS) score at 6 weeks after delivery. Record the Pittsburgh Sleep Quality Index (PSQI) scores of patients during pregnancy and 3 days postpartum, and measure the levels of serum interleukin-1 β (IL-1 β) and tumor necrosis factor - α (TNF - α) in patients.

Results The PSQI scores of the PPD group in early pregnancy, mid pregnancy, late pregnancy, and 3 days postpartum were all higher than those of the non PPD group, with statistical differences (P<0.05). Correlation analysis showed that there was a positive correlation between PSQI score and EPDS score in GDM patients (P<0.05). The serum levels of IL-1 β and TNF - α in the PPD group were higher than those in the non PPD group, with statistical differences (P<0.05).

Conclusion   Sleep disorders during pregnancy and early postpartum period in GDM patients are associated with the occurrence of PPD, and elevated serum levels of IL-1 β and TNF - α can also increase the risk of PPD. Combining the association between sleep disorders, elevated inflammatory factors, and PPD, it suggests that chronic inflammation may be a potential biological pathway through which sleep disorders affect the risk of PPD, and is worthy of further research.

Key words: 【Key words】 Gestational diabetes mellitus; Sleep disorders; Postpartum depression;Correlation