摘要

【摘要】
目的 探讨妊娠期高血压（PIH）孕晚期患者抑郁状态与血清炎性因子水平的相关性。

方法 病例组为本院妇产科2022年1月至2024年1月收治的96例PIH患者，对照组为本院同期产检血压正常的60例孕妇，采用汉密尔顿抑郁量表（HAMD）和贝克抑郁自评量表（BDI）评估PIH患者抑郁发生情况；对比抑郁组和PIH组孕妇血清中血压[收缩压、舒张压]水平与血清中炎症因子[白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）]和氧化应激指标[谷胱甘肽过氧化物酶（GSH-PX）、丙二醛（MDA）、超氧化物歧化酶（SOD）]水平；并对比不同抑郁程度PIH孕妇血清炎性因子与氧化应激指标水平。

结果 96例PIH孕晚期孕妇中，57例发生抑郁，其中：轻度抑郁38例，中度抑郁13例，重度抑郁6例，且HAMD得分（14.12±2.68）分，BDI得分（15.08±2.54）分。总体为轻度抑郁状态。与无抑郁的PIH组比较，轻度抑郁组、中度抑郁组、重度抑郁组PIH孕妇血清中IL-6、TNF-α、CRP及MDA水平均显著较高（P<0.05），GSH-PX、SOD水平均显著较低（P<0.05）。与PIH组比，抑郁组孕妇TC无显著改变（P>0.05），TG、LDL-C、FBG及收缩压、舒张压水平均显著较高（P<0.05），HDL-C水平显著较低（P<0.05）。抑郁组孕妇IL-6、TNF-α、CRP及MDA水平均显著高于PIH组（P<0.05）；病例组GSH-PX、SOD水平均显著低于PIH组（P<0.05）。

结论 PIH孕晚期孕妇血清中炎性因子及MDA水平升高，GSH-PX、SOD水平降低，且随着抑郁程度加重，炎性因子及MDA水平越高，GSH-PX、SOD水平越低。

关键词：【关键词】妊娠期高血压；炎性因子；氧化应激指标；抑郁；严重程度

ABSTRACT

[Abstract]
Objective To explore the correlation of depression status with levels of serum inflammatory factors in patients with pregnancy-induced hypertension (PIH) in late pregnancy.

Methods The case group included 96 patients with PIH in department of obstetrics and gynecology of the hospital from January 2022 to January 2024, and the control group was consisted of 60 pregnant women with normal blood pressure during prenatal examination. Hamilton Depression Scale (HAMD) and Beck Depression Inventory (BDI) were used to evaluate the occurrence of depression in PIH patients. The blood pressure (systolic blood pressure, diastolic blood pressure) and serum inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP)] and oxidative stress indicators [glutathione peroxidase (GSH-PX), malondialdehyde (MDA), superoxide dismutase (SOD)] were compared the depression group and the PIH group. The levels of serum inflammatory factors and oxidative stress indicators were compared among PIH pregnant women with different degrees of depression.

Results Among the 96 pregnant women with PIH in late pregnancy, 57 cases had depression, including 38 cases of mild depression, 13 cases of moderate depression and 6 cases of severe depression. The HAMD score and BDI score were (14.12±2.68) points and (15.08±2.54) points, demonstrating overall mild depression. Compared with non-depressive PIH group, the levels of serum IL-6, TNF-α, CRP and MDA of PIH pregnant women in mild depression group, moderate depression group and severe depression group were significantly higher (P<0.05) while the GSH-PX and SOD levels were significantly lower (P<0.05). Compared with the PIH group, there was no significant change in TC in the depression group (P>0.05), and the levels of TG, LDL-C and FBG, systolic blood pressure and diastolic blood pressure were significantly higher (P<0.05) while the level of HDL-C was significantly lower (P<0.05). The levels of IL-6, TNF-α, CRP and MDA in the depression group were significantly higher than those in the PIH group (P<0.05) while the levels of GSH-PX and SOD were significantly lower (P<0.05).

Conclusion   The levels of serum inflammatory factors and MDA of pregnant women with PIH in late pregnancy are increased while the levels of GSH-PX and SOD are decreased. With the aggravation of depression degree, the higher the levels of inflammatory factors and MDA, the lower the levels of GSH-PX and SOD.

Key words: [Key words] Pregnancy-induced hypertension; Inflammatory factors; Oxidative stress indicators; Depression; Severity