摘要

【摘要】
目的 观察双相情感障碍（bipolar disorder，BD）不同病情严重程度患者血清半乳糖凝集素-3（galectin-3）、神经生长因子（nerve growth factor，NGF）水平。

方法 回顾性收集2023年12月至2024年12月期间在我院接受诊治的BD患者临床数据共计80例。依据汉密尔顿抑郁量表-24（Hamilton depression scale-24，HAMD-24）和杨氏躁狂量表（Young mania rating scale，YMRS）评估BD患者发作状态，分为抑郁发作组（HAMD-24＞8分，n=36）、躁狂发作组（YMRS评分＞6分，n=27）和混合发作组（HAMD-24＞8分且YMRS＞6分，n=17）。同时采用临床总体印象-严重程度量表（clinical globalimpression-severity scale，CGI-S）评估BD患者病情严重程度，分为轻度组（1~2分，n=40）、中度组（3~4分，n=24）和重度组（5~7分，n=16）。比较不同发作状态及不同病情严重程度患者血清galectin-3、NGF水平，相关性分析BD患者病情严重程度与血清galectin-3、NGF水平的关系。

结果 混合发作组BD患者血清galectin-3水平高于抑郁发作组、躁狂发作组，NGF水平低于抑郁发作组、躁狂发作组（P＜0.05）。重度组BD患者血清galectin-3水平高于中度组、轻度组，NGF水平低于中度组、轻度组；且中度组血清galectin-3水平高于轻度组，NGF水平低于轻度组（P＜0.05）。相关性分析表明，BD患者CGI-S评分与血清galectin-3水平呈正相关，与NGF水平呈负相关（P＜0.05）。

结论 血清galectin-3和NGF水平可反映BD患者不同发作状态及病情严重程度，且血清galectin-3和NGF水平与病情严重程度密切相关。

关键词： 【关键词】双相情感障碍；病情严重程度；半乳糖凝集素-3；神经生长因子

ABSTRACT

【Abstract】
Objective To observe the levels of serum galectin-3 and nerve growth factor (NGF) in patients with different severity levels of bipolar disorder (BD).

Methods A total of 80 clinical data of BD patients who were diagnosed and treated in our hospital from December 2023 to December 2024 were retrospectively collected. According to the Hamilton Depression Scale-24 (HAMD-24) and Young Mania Rating Scale (YMRS), patients with BD were evaluated for their seizure status and divided into a depressive episode group (HAMD-24>8 points, n=36）、 The manic episode group (YMRS score>6, n=27) and the mixed episode group (HAMD-24>8 and YMRS>6, n=17）。 At the same time, the Clinical Global Impression Severity Scale (CGI-S) was used to assess the severity of BD patients, who were divided into mild group (1-2 points, n=40), moderate group (3-4 points, n=24), and severe group (5-7 points, n=16). Compare the levels of serum galectin-3 and NGF in patients with different seizure states and different severity levels of the disease, and conduct a correlation analysis on the relationship between the severity of the disease and the levels of serum galectin-3 and NGF in BD patients.

Results The serum galectin-3 level of BD patients in the mixed seizure group was higher than that in the depressive seizure group and the manic seizure group, while the NGF level was lower than that in the depressive seizure group and the manic seizure group (P<0.05). The serum galectin-3 level of BD patients in the severe group was higher than that in the moderate group and the mild group, while the NGF level was lower than that in the moderate group and the mild group. Moreover, the serum galectin-3 level in the moderate group was higher than that in the mild group, and the NGF level was lower than that in the mild group (P<0.05). Correlation analysis indicated that the CGI-S score of BD patients was positively correlated with the serum galectin-3 level and negatively correlated with the NGF level (P<0.05).

Conclusion   The levels of serum galectin-3 and NGF can reflect different seizure states and severity of the disease in patients with BD, and the levels of serum galectin-3 and NGF are closely related to the severity of the disease.

Key words: 【Key words】Bipolar disorder; Severity of illness; Galectin-3; Nerve growth factor