摘要

【摘要】
目的 分析青少年抑郁障碍患者睡眠障碍与抗抑郁药疗效的相关性。

方法 2022年3月～2025年3月本院收治124青少年抑郁障碍患者，采用匹兹堡睡眠质量指数（Pittsburgh Sleep Quality Index，PSQI）对124例患者的睡眠质量进行评估，124例患者分为无睡眠障碍组（n=21）、轻度睡眠障碍组（n=53）和中重度睡眠障碍组（n=50）。记录三组临床疗效、汉密尔顿抑郁量表17项（Hamilton Depression Rating Scale-17 items，HAMD-17）评分，分析患者睡眠障碍与抗抑郁药疗效（治疗总有效率、HAMD-17评分改善值）的相关性。

结果 无睡眠障碍组、轻度睡眠障碍组的总有效率高于中重度睡眠障碍组（P＜0.05）；治疗后，三组HAMD-17评分比较，无睡眠障碍组低于轻度睡眠障碍组，轻度睡眠障碍组低于中重度睡眠障碍组（P＜0.05）；HAMD-17评分改善值比较，无睡眠障碍组大于轻度睡眠障碍组，轻度睡眠障碍组大于中重度睡眠障碍组（P＜0.05）；睡眠障碍程度与治疗总有效率存在负相关关系，与HAMD-17评分改善值存在正相关关系（P＜0.05）。

结论 青少年抑郁障碍患者的基线睡眠障碍严重程度与抗抑郁药疗效呈显著负相关，即睡眠问题越严重，其在抗抑郁药治疗中的获益越差，HAMD-17评分改善幅度越小。

关键词：【关键词】 青少年；抑郁障碍；睡眠障碍；抗抑郁药；疗效；相关性

ABSTRACT

【Abstract】
Objective To analyze the correlation between sleep disorders and the efficacy of antidepressants in adolescent patients with depressive disorders.

Methods From March 2022 to March 2025, 124 adolescent patients with depressive disorders were admitted to our hospital. The Sleep Quality of 124 patients was evaluated using the Pittsburgh Sleep Quality Index (PSQI). A total of 124 patients were divided into the no sleep disorder group (n=21), the mild sleep disorder group (n=53), and the moderate to severe sleep disorder group (n=50).The clinical efficacy of the three groups and the score of Hamilton Depression Rating Scale-17 items (HAMD-17) were recorded. The correlation between sleep disorders in patients and the efficacy of antidepressants (total effective rate of treatment, improvement value of HAMD-17 score) was analyzed.

Results The total effective rate of the non-sleep disorder group and the mild sleep disorder group was higher than that of the moderate to severe sleep disorder group (P < 0.05). After treatment, the HAMD-17 scores of the three groups were compared. The score of the non-sleep disorder group was lower than that of the mild sleep disorder group, and the score of the mild sleep disorder group was lower than that of the moderate to severe sleep disorder group (P < 0.05).Comparison of the improvement values of HAMD-17 scores: The group without sleep disorders was greater than the group with mild sleep disorders, and the group with mild sleep disorders was greater than the group with moderate to severe sleep disorders (P < 0.05); The degree of sleep disorders was negatively correlated with the total effective rate of treatment, and positively correlated with the improvement value of HAMD-17 score (P < 0.05).

Conclusion   The severity of baseline sleep disorders in adolescent patients with depressive disorders is significantly negatively correlated with the efficacy of antidepressants. That is, the more severe the sleep problem, the worse the benefit from antidepressant treatment, and the smaller the improvement in the HAMD-17 score.

Key words: 【Key words】 Adolescents; Depressive disorders; Sleep disorders; Antidepressants; Efficacy; Correlation