摘要

【摘要】
目的：探讨双相情感障碍（bipolar disorder，BD）患者临床特征、甲状腺功能变化的性别差异，并分析其与血清维生素D水平的相关性。

方法：选取2023年4月～2025年4月在我院诊治的151例BD患者，比较不同性别BD患者的临床特征、甲状腺功能和维生素D水平变化，并分析BD患者的临床特征、甲状腺功能与甲状腺功能和维生素D水平变化的相关性。

结果：不同性别BD患者住院天数、伴精神病性症状、首发症状、使用抗抑郁药物存在差异（P<0.05）。不同性别总三碘甲状腺原氨酸（Total Triiodothyronine，TT3）、总甲状腺素（Total Thyroxine，TT4）、游离甲状腺素（Free Thyroxine‌，FT4）、促甲状腺激素（Thyrotropin，TSH）、维生素D水平治疗前后差值有统计学意义（P<0.05）。经Spearman分析，女性、使用抗抑郁药物与维生素D水平差值呈负相关（P<0.05），经Pearson分析，TT3差值、FT4差值与维生素D水平差值呈正相关（P<0.05），TSH差值差值与维生素D水平差值呈负相关（P<0.05）。

结论：BD患者床特征及甲状腺功能指标（TT4、FT4、TSH）存在显著的性别差异，且与血清维生素D水平的变化密切相关。

关键词：【关键词】双相情感障碍；临床特征；甲状腺功能；维生素D水平；相关性

ABSTRACT

【Abstract】
Objective：Explore the gender differences in clinical characteristics and thyroid function changes of patients with bipolar disorder (BD), and analyze their correlation with serum vitamin D levels.

Methods：Select 151 BD patients treated in our hospital from April 2023 to April 2025, compare the clinical characteristics, thyroid function, and changes in vitamin D levels of BD patients of different genders, and analyze the correlation between clinical characteristics, thyroid function, and changes in thyroid function and vitamin D levels of BD patients.Result：There was a statistically significant difference in the levels of total Triiodothyronine (TT3), Total Thyroxine (TT4), Free Thyroxine of different genders (FT4), thyroid stimulating hormone (TSH) and vitamin D before and after treatment (P<0.05). According to Spearman analysis, there was a negative correlation (P<0.05) between the use of antidepressants and vitamin D levels in women. Pearson analysis showed a positive correlation (P<0.05) between TT3 and FT4 levels and vitamin D levels, and a negative correlation (P<0.05) between TSH and vitamin D levels.

Conclusion  :There are significant gender differences in bed characteristics and thyroid function indicators (TT4, FT4, TSH) of BD patients, which are closely related to changes in serum vitamin D levels.

Key words: 【Key words】Bipolar disorder; Clinical features; Thyroid function; Vitamin D levels; relevance