摘要

摘要：
目的 探讨合并抑郁对经皮冠状动脉介入术（percutaneous coronary intervention，PCI）后心肌损伤标志物及心率变异性的影响。

方法 选择2023年3月-2025年5月103例冠心病患者，评估抑郁自评量表并分为抑郁组与无抑郁组，PCI术后检测心肌损伤标志物[心肌肌钙蛋白I（cardiac troponin，cTnI）、肌酸激酶同工酶(creatine kinase isoenzyme, CK-MB)]、心率变异性 (SDNN、SDANN、LF/HF)。

结果 103例冠心病患者38例合并抑郁情绪；抑郁组PCI术后血清cTnI、CK-MB均显著高于无抑郁组，（P<0.05）；抑郁组PCI术后SDNN、SDANN低于无抑郁组，LF/HF高于无抑郁组，（P<0.05）。

结论 冠心病患者容易出现抑郁情绪，而且，合并抑郁情绪术后心肌损伤标志物水平更高，心率变异性更差。

关键词：关键词：抑郁；冠心病；经皮冠状动脉介入术；心肌损伤标志物；心率变异性

ABSTRACT

[Abstract]
Objective To investigate the impact of comorbid depression on myocardial injury markers and heart rate variability following percutaneous coronary intervention (PCI).

Methods A total of 103 patients with coronary heart disease were enrolled between March 2023 and May 2025. Participants were assessed using the Self-Rating Depression Scale and categorized into depressed and non-depressed groups. Post-PCI monitoring of myocardial injury markers [cardiac troponin I (cTnI), creatine kinase isoenzyme (CK-MB)] and heart rate variability (SDNN, SDANN, LF/HF).

Results Among 103 patients with coronary heart disease, 38 also experienced depressive symptoms. Post-PCI serum cTnI and CK-MB levels were significantly higher in the depressed group than in the non-depressed group (P<0.05). Post-PCI SDNN and SDANN were lower in the depressed group, while LF/HF was higher compared to the non-depressed group (P<0.05).

Conclusion   Patients with coronary heart disease are prone to depressive symptoms. Furthermore, those with comorbid depression exhibit higher levels of postoperative myocardial injury markers and poorer heart rate variability.

Key words: Key words Depression; Coronary Heart Disease; Percutaneous Coronary Intervention; Cardiac Injury Markers; Heart Rate Variability