摘要

[摘要]
目的 探讨非小细胞肺癌（non-small cell lung cancer, NSCLC）化疗患者主要照顾者疾病负担、预期性悲伤调查及其影响因素分析。

方法 选取2019年5月-2024年5月在本院进行化疗的NSCLC患者580例作为研究对象，调查NSCLC化疗患者主要照顾者疾病负担[采用照顾者负担量表（Zarit burden interview, ZBI）评估]、预期性悲伤[采用预期性悲伤评估量表（anticipatory grief scale, AGS）评估]，并采用多元线性回归分析其影响因素。

结果 580例NSCLC化疗患者，ZBI总分为（32.29±6.44）分、AGS总分为（77.53±9.63）分；多元线性回归分析显示，化疗相关并发症＞2种、主要照顾者为患者配偶、照顾时间＞6 h/d均为影响NSCLC化疗患者主要照顾者疾病负担的独立危险因素（P<0.05）；多元线性回归分析显示，原发肿瘤-淋巴结-远处转移分期系统（Tumor Node Metastasis Staging System, TNM）Ⅳ期、化疗相关并发症＞2种、主要照顾者为患者配偶、照顾时间＞6 h/d、主要照顾者心理弹性低水平均为影响NSCLC化疗患者主要照顾者预期性悲伤的独立危险因素（P<0.05）。

结论 NSCLC化疗患者主要照顾者疾病负担、预期性悲伤水平较高，临床可基于TNM分期、化疗相关并发症、与患者关系、照顾时间、主要照顾者心理弹性等进行干预，以提高照顾质量。

关键词：[关键词] 非小细胞肺癌；主要照顾者；疾病负担；预期性悲伤；影响因素

ABSTRACT

[Abstract]
Objective To investigate disease burden and anticipatory grief in primary caregivers of chemotherapy patients with non-small cell lung cancer (NSCLC), and to analyze their influencing factors.

Methods A total of 580 patients with NSCLC undergoing chemotherapy in the hospital were enrolled as the research objects between May 2019 and May 2024. The disease burden [Zarit burden interview (ZBI)] and anticipatory grief [anticipatory grief scale (AGS)] in primary caregivers were investigated, and and their influencing factors were analyzed by multiple linear regression analysis.

Results The total score of ZBI and AGS in the 580 patients were (32.29±6.44) points and (77.53±9.63) points. Multiple linear regression analysis showed chemotherapy-related complications >2 kinds, spouse as the main caregiver and care time >6 h/d were all independent risk factors of disease burden (P<0.05). Multiple linear regression analysis showed that Tumor Node Metastasis Staging System(TNM) at stage IV, chemotherapy-related complications >2 kinds, spouse as the main caregiver, care time >6 h/d and low psychological resilience were all independent risk factors of anticipatory grief (P<0.05).

Conclusion   The disease burden and anticipatory grief are high in primary caregivers of chemotherapy patients with NSCLC. Clinically, intervention can be taken based on TNM staging, chemotherapy-related complications, relationship with patients, care time and psychological resilience of primary caregivers to improve nursing quality.

Key words: [Key words] Non-small cell lung cancer; Primary caregiver; Disease burden; Anticipatory grief; Influencing factor