摘要

【摘要】
目的 探究反复发作哮喘患儿的血清炎症因子水平变化，并分析其与睡眠质量及负性情绪的相关性。

方法 纳入医院2022年1月至2025年1月的95例反复哮喘患儿作为观察组，对照组为同期招募的80名健康体检儿童。对所有参与者进行血清炎症因子[C反应蛋白（CRP）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）]检测。睡眠质量、负性情绪通过儿童睡眠习惯问卷（CSHQ）、儿童焦虑性情绪障碍筛查表（SCARED）和儿童抑郁量表（CDI）进行测评。比较两组间各指标差异，并采用Pearson相关性分析探讨哮喘患儿血清炎症水平与睡眠质量、负性情绪评分的相关性。

结果 与对照组相比，观察组患儿血清CRP、IL-6、TNF-α水平均显著升高（均P<0.05）；CSHQ评分、SCARED评分、CDI评分均显著增高（均P<0.05）。相关性分析显示，哮喘组患儿血清CRP、IL-6、TNF-α水平与CSHQ评分、SCARED评分、CDI评分均呈正相关（均P<0.05）。

结论 反复哮喘患儿血清炎症水平升高，睡眠质量降低，焦虑、抑郁情绪加重，且炎症因子其与睡眠质量及负性情绪密切相关。

关键词：【关键词】 支气管哮喘；儿童；炎症因子；睡眠质量；焦虑；抑郁；相关性分析

ABSTRACT

[Abstract]
Objective To examine the variations in serum inflammatory markers among children with recurrent asthma and their interconnections with sleep quality and negative emotional states.

Methods During the study period from January 2022 to January 2025, 95 children diagnosed with recurrent asthma were selected for the observation group. The control group was drawn from 80 healthy children undergoing physical examinations during the same period. All subjects underwent evaluation for inflammatory markers [C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)]. To assess sleep patterns and emotional status, the Children's Sleep Habits Questionnaire (CSHQ), the Screen for Child Anxiety Related Emotional Disorders (SCARED), and the Children's Depression Inventory (CDI) were employed. A comparative analysis of all variables was undertaken between the two groups. Pearson's correlation coefficient was utilised to ascertain the relationship between serum inflammatory levels and sleep quality as well as negative emotion scores in children with asthma.

Results Relative to the control group, significantly higher concentrations of CRP, IL-6, and TNF-α were observed in the asthma group (P<0.05). Similarly, their scores on the CSHQ, SCARED, and CDI scales were also significantly greater (P<0.05). Subsequent analysis demonstrated that in children with asthma, serum levels of these inflammatory factors were positively correlated with the obtained sleep and negative emotion scores (P<0.05).

Conclusion   Children with recurrent asthma exhibit elevated serum inflammatory levels, reduced sleep quality, and increased anxiety and depression. Furthermore, inflammatory factors are significantly correlated with both sleep quality and negative emotions.

Key words: [Keywords]Bronchial asthma; Children; Inflammatory factors; Sleep quality; Anxiety; Depression; Correlation analysis