摘要

【摘要】
目的 探讨奥氮平联合脑循环治疗仪治疗精神分裂症的临床疗效。

方法 选择2023年12月-2025年6月105例精神分裂症患者，数字表法随机分组，对照组52例采用奥氮平治疗，观察组53例联合脑循环治疗仪治疗。比较两组阳性与阴性症状量表、社会功能缺陷量表（social disability screening schedule，SDSS）以及简易精神状态量表。

结果 两组治疗后精神评分均显著下降，但观察组治疗后阴性症状评分显著低于对照组，（P<0.05），其余2项评分差异无统计学意义（P>0.05）；两组治疗后认知功能评分显著升高，SDSS评分显著降低，但观察组治疗后2项评分均优于对照组（P＜0.05）；两组不良反应发生率差异无统计学意义（P>0.05）。

结论 奥氮平联合脑循环治疗仪治疗精神分裂症能够减轻阴性症状，促进社会、认知功能改善，治疗安全。

关键词：关键词：奥氮平；脑循环治疗仪；精神分裂症；认知功能；社会功能

ABSTRACT

[Abstract]
Objective To investigate the clinical efficacy of olanzapine combined with a cerebral circulation therapeutic apparatus in the treatment of schizophrenia.

Methods A total of 105 patients with schizophrenia, admitted between December 2023 and June 2025, were randomly assigned using a digital table method. The control group (n=52) received olanzapine alone, while the observation group (n=53) received olanzapine combined with the cerebral circulation therapeutic apparatus. The Positive and Negative Syndrome Scale (PANSS), social disability screening schedule (SDSS), and Mini-Mental State Examination (MMSE) were compared between the two groups.

Results After treatment, psychiatric symptom scores significantly decreased in both groups. The observation group showed significantly lower negative symptom scores compared with the control group (P < 0.05), whereas differences in the other two symptom scores were not statistically significant (P > 0.05). After treatment, the cognitive function scores of both groups significantly increased, and the SDSS scores significantly decreased. However, both scores of the observation group were better than those of the control group after treatment (P < 0.05). The incidence of adverse reactions did not differ significantly between the two groups (P > 0.05).

Conclusion   Olanzapine combined with a cerebral circulation therapeutic apparatus can alleviate negative symptoms of schizophrenia and promote improvements in social and cognitive functioning, with a favorable safety profile.

Key words: Key words Olanzapine; Cerebral Circulation Therapeutic Apparatus; Schizophrenia; Cognitive Function; Social Function