摘要

【摘要】
目的 调查焦虑抑郁状态在变应性鼻炎(allergic rhinitis，AR)中的发病情况及其与临床症状、血清免疫球蛋白E(Immunoglobulin E, IgE)、生活质量的相关性。

方法 纳入2023年12月-2025年4月400例AR患者以及100例健康体检人员，调查并比较AR患者在抑郁自评量表(Self-rating depression scale, SDS)、焦虑自评量表(self-rating anxiety scale, SAS)方面与健康体检人员的差异。AR患者根据是否具有焦虑或（和）抑郁情绪进一步分为焦虑抑郁组与无焦虑抑郁组，比较两组鼻部症状总评分、IgE水平、鼻结膜炎生活质量问卷的差异，并分析SDS评分、SAS评分与之相关性。

结果 AR患者SDS评分、SAS评分显著高于健康体检人员（P<0.05）；AR患者中88例（22.00%）处于焦虑抑郁状态，焦虑抑郁组SDS评分、SAS评分均显著高于无焦虑抑郁组，（P<0.05）；焦虑抑郁组症状总评分、生活质量评分、血清IgE均显著高于无焦虑抑郁组（312例）（P<0.05）；焦虑抑郁组SDS评分、SAS评分与症状总评分、生活质量评分、血清IgE均呈正相关关系（P<0.05）。

结论 AR患者中存在一定比例的焦虑/抑郁情绪亚群，且焦虑、抑郁情绪与AR临床症状、IgE、生活质量显著相关。

关键词：【关键词】变应性鼻炎；焦虑抑郁；临床症状；血清免疫球蛋白E；生活质量

ABSTRACT

【Abstract】
Objective To investigate the detection rate of anxiety and depression in patients with AR and their correlation with clinical symptoms, Immunoglobulin E（IgE） and quality of life.

Methods A total of 400 AR patients and 100 healthy individuals who underwent physical examinations from December 2023 to April 2025 were included, and the AR group and the control group were established. The self rating Depression Scale (SDS) and Self rating Anxiety Scale (SAS) were Investigated and compared. AR patients were divided into the anxiety depression group and the non anxiety depression group based on whether they have anxiety and depression emotions. The total scores of nasal symptoms, quality of life questionnaire for nasal conjunctivitis, and serum IgE between two groups were compared. The correlation between SDS score and SAS score were analyzed.

Results The SDS and SAS scores of the AR group were significantly higher than those of the control group (P<0.05). The total symptom score, quality of life score, and serum IgE in the anxiety and depression group (88 cases) were significantly higher than those in the non anxiety and depression group (312 cases) (P<0.05). The SDS and SAS scores of the anxiety and depression group were significantly higher than those of the non-anxiety and depression group (P < 0.05).The SDS score and SAS score of the anxiety and depression group were positively correlation with the total symptom score, quality of life score, and serum IgE (P<0.05).

Conclusion   The detection rate of anxiety and depression in AR patients is relatively high, and anxiety and depression are significantly correlated with AR clinical symptoms, IgE and quality of life.

Key words: 【Key words】Allergic Rhinitis; Anxiety and Depression; Clinical Symptoms; Quality of Life