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氟西汀联合常规治疗伴强迫症状精神分裂症患者的疗效及不良反应观察

  • 王翠

* 通信作者: 王翠, 单位:

摘要


目的:观察氟西汀联合常规疗法治疗具有强迫症状精神分裂症患者的有效性与安全性;

方法:选择2013年1月至2015年12月期间,在我院接受治疗的具有强迫症状精神分裂症患者201例,将入组患者随机分为氟西汀组(102例)与对照组(99例)两组,氟西汀组患者接受氟西汀联合常规治疗,对照组患者仅接受常规治疗,比较两组之间疗效与安全性差异;

结果:对比对照组,氟西汀组在接受治疗后,耶鲁-布朗评分(Y-BOCS评分)及宽容性评分(TO评分)均明显降低(P<0.05);两组对比,简明精神病量表(BPRS)评分及安全性评价不良反应量表(TESS评分)均无明显差别(P>0.05);

结论:氟西汀联合常规治疗可以明显缓解精神分裂症患者强迫症状,改善患者社交信任与宽容程度,具有一定疗效与安全性。

关键词:精神分裂症,强迫症状,氟西汀

ABSTRACT

OBJECT: To elevate the efficacy and safety of fluoxetine combined with conventional therapy in the schizophrenia patients with obsessive-compulsive symptoms; METHODS: We chose the 201 cases during January 2013 to December 2015 in our hospital. The whole patients were randomly divided into the fluoxetine group (102 cases), who received fluoxetine combined with conventional treatment, and the control group (99 cases), only received routine treatment. And then we evaluated the efficacy and the safety after a course of treatment; RESULTS: Compared with the control group, after receiving treatment, the Yale Brown obsessive (Y-BCOS) score and tolerance (TO) score of the fluoxetine group were significantly decreased (P < 0.05); But about the Brief Psychiatric Rating Scale(BPRS) and Treatment Emergent Symptom Scale(TESS), there were no significant difference between the two groups (P > 0.05);CONCLUSION: Combined with the routine therapy, the fluoxetine could improve the obsessive-compulsive symptom.

Key words: Schizophrenia, Obsessive-Compulsive disorder, Fluoxetine.

引用本文 / How to Cite This Article

王翠.氟西汀联合常规治疗伴强迫症状精神分裂症患者的疗效及不良反应观察[J]. 国际精神病学杂志, 2017, 44(1): 33-36

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