摘要

【摘要】
目的：探讨分析阿立哌唑与利培酮治疗难治性精神分裂症的临床疗效及对患者糖脂代谢水平的影响。

方法：选取2014年4月-2016年5月期间我院收治的难治性精神分裂症患者160例，依据治疗方式的不同随机分为两组，对照组采用氯氮平联合利培酮治疗，研究组采用氯氮平联合阿立哌唑治疗。

结果：治疗过程中研究组患者不良反应的发生率明显低于对照组（P＜0.05）；研究组与对照组患者的治疗有效率分别为92.5%、78.7%，存在明显区别（P＜0.05）；治疗后对照组患者的糖脂代谢各项指标水平均明显高于治疗前（P＜0.05），研究组患者的糖脂代谢各项指标水平与治疗前无明显差异（P＞0.05）。

结论：采用氯氮平联合阿立哌唑治疗难治性精神分裂症，可以有效改善患者的精神状况，减少不良反应发生，维持糖脂代谢水平稳定。

关键词：【关键词】阿立哌唑；利培酮；难治性精神分裂症；糖脂代谢水平；临床疗效

ABSTRACT

【Abstract】
Objective: To investigate the clinical efficacy of aripiprazole and risperidone in the treatment of refractory schizophrenia and its influence on the level of glucose and lipid metabolism.

Methods: 160 patients with refractory schizophrenia treated in our hospital from April 2014 to May -2016 were randomly divided into two groups. The control group was treated with clozapine combined with risperidone, and the study group was treated with clozapine combined with aripiprazole.

Results: the treatment process in the study group the incidence of adverse reaction was significantly lower than the control group (P < 0.05); the study group and the control group of patients with treatment efficiency were 92.5%, 78.7%, has the obvious difference (P < 0.05); the control group of the glucose and lipid metabolism in patients after treatment was significantly higher than the average index of water treatment before (P < 0.05), metabolism of glucose and lipid levels of the indicators and treatment of patients in the study group, no significant differences (P, 0.05).

Conclusion  : Clozapine Combined with aripiprazole in the treatment of refractory schizophrenia can effectively improve the mental status of patients, reduce the incidence of adverse reactions, and maintain the stability of glucose and lipid metabolism.

Key words: 【keywords】Aripiprazole; Risperidone; Refractory Schizophrenia; Glycolipid metabolism; Clinical efficacy